CVRI T32 Molecular and Cellular Basis of Cardiovascular Disease

This NIH T32 funded training program is exclusively postdoctoral.  To maximize the impact of this T32 and the number of trainees exposed to its rigorous standards and activities, 8 trainees will be appointed each year for a single year of T32 funding, then rotate off to support provided by individual fellowship grants, grants on which the mentor is PI or other laboratory funds.  All trainees will hold PhD, MD, or MD/PhD degrees. Two T32-funded positions will be dedicated to MD or MD/PhD Cardiology fellows (or occasionally other clinical fellows in disciplines relevant to cardiovascular biology and disease) seeking rigorous training in patient-based research through UCSF's TICR program.  The remaining trainees will be a mix of PhD, MD, and MD/PhD trainees recruited into CVRI laboratories by individual mentors.

All trainees appointed to the T32 are required to take the Responsible Conduct of Research course.  In addition, MD-trained program trainees engaged in clinical research have the option to take formal coursework for training or advanced training in clinical research.  Partial tuition for TICR-based trainees will be covered by the program.  Opportunities for Laboratory-based Research Track appointees are also available – the trainee will discuss possible coursework opportunities with the Advisor and primary mentor in their initial meeting.  Trainees will be encouraged to take the graduate school course(s) relevant to their areas of interest if they have not had similar courses in their prior training.

Although coursework is available, the heart of this training program is formulation and execution of a substantial research project relevant to cardiovascular biology and disease (broadly defined) and development of professional skills under the guidance of a faculty mentor.  This core research training is supplemented by co-, group- and peer-mentoring, and by coursework tailored to a trainee’s specific needs.  Coursework is particularly intensive for the TICR track, which grounds MD-trained appointees in clinical research.  In the laboratory-based research track, trainees have usually selected a primary mentor and apply to the program with support from that investigator.  Entering Cardiology fellows who apply to the laboratory-based research track or TICR tracks will be aided in their selection of a primary mentor by Dr. Javid Moslehi.  When the primary mentor is a junior faculty member, an advisory committee of co-mentors is provided.  Otherwise, the primary mentor and trainee select co-mentors as appropriate for complementary knowledge and skills that support the project.  Group and peer mentoring will occur in CVRIPS at which trainees present ongoing work to the entire community, laboratory group meetings, thematic research-in-progress groups, daily interactions in the laboratory, and other venues to facilitate formal and informal scientific interaction.

To apply for a position on the CVRI’s T32, please send by email a cover letter including a brief statement of your research interests and accomplishments with your curriculum vitae directly to the Program Faculty Member/s of interest to you. Applications to the NIH T32 training grant will be made jointly with the faculty member.  Program faculty members are listed below.

Christopher Allen(link is external)
Mechanisms of allergic lung inflammation

Kaveh Ashrafi(link is external)
Metabolic regulation of neural functions during aging

Kamran Atabai(link is external)
Limiting fibrosis through cell-mediated collagen turnover

Brian Black(link is external)
Gene Regulatory Networks in cardiovascular development and regeneration

Benoit Bruneau(link is external)
Heart development/congenital heart disease

Abigail Buchwalter(link is external)
Function and dynamic regulation of the nuclear lamina

Daniele Canzio(link is external)
Regulation of clustered Protocadherins;neuronal cell-surface diversity

John Chorba(link is external)
Chemical Biology of Cardiometabolic Disease

Jan Christoph(link is external)
Computational cardiology, cardiac arrhythmia mechanisms and imaging 

Pao-Tien Chuang(link is external)
The mechanisms of lung branching and alveolar formation

William Degrado(link is external)
Protein Design, Drug Design, Integrin structure/function, Fibrosis

John Fahy(link is external)
Airway biology and molecular phenotypes of airway diseases

Trevor Fidler(link is external)
Macrophages and atherosclerosis

Jeffrey R. Fineman      (link is external)          
Pediatric Pulmonary Vascular Disorders

Edward Gerstenfeld(link is external)
Mechanism of ectopy induced remodeling in cardiac arrhythmias

Douglas Gould(link is external)
Biological functions and pathogenic contributions of extracellular matrix

Michael Grabe(link is external)
Computational approaches to structure/function of membrane proteins

Akiko Hata(link is external)
Pathogenesis of vascular disease and deregulation of TGFbeta signaling

Robert A. Hiatt(link is external)                       
Epidemiology; cancer; social determinants; health disparities

Guo Huang(link is external)
Heart regeneration

Roshanak Irannejad(link is external)              
Subcellular GPCR signaling in the cardiovascular system

Isha Jain(link is external)                                
Oxygen and vitamin metabolism and treatment

Lily Jan(link is external)
Studies of calcium-activated ion channels and lipid scramblases

David Julius(link is external)
Molecular biology of somatosensation and pain

Natalia Jura(link is external)
Regulation of growth factor signaling by ubiquitination

Tom Kornberg(link is external)
Organogenesis and patterning during Drosophila development

Mark Looney(link is external)                          
Immunobiology of the normal and injured lung

Dengke Ma(link is external)
Molecular genetic basis of physiological resilience in animals

Takashi Mikawa(link is external)
Developmental regulation of organogenesis

Daniel Minor(link is external)
Structure, function, and pharmacology of ion channels

Javid J. Moslehi(link is external)                    
Cardiovascular complications of novel targeted cancer therapies

Maxence V. Nachury(link is external)              
Quality control of the primary cilium proteome

Jose Angel Nicolas-Avila(link is external)       
Macrophages and cardiovascular quality control

Elphege P. Nora(link is external)                     
Chromosome biology and genomics

Jeffrey Olgin(link is external)
Mechanisms of arrhythmias

Akinyemi Oni-Orisan(link is external)             
Pharmaco-genomics

Jeremy Reiter(link is external)
Signaling at the primary cilium, the cell's antenna

Dean Sheppard(link is external)                    
In vivo biology of integrins

Kevan M. Shokat(link is external)                   
Chemical approaches to deciphering and controlling signal transduction 

Xiaokun Shu(link is external)
Protein engineering; Fluorescence reporters; biomolecular condensates

Anthony K. Shum(link is external)                   
Study of the intersection of autoimmunity with cardiopulmonary disease

Deepak Srivastava(link is external)
Molecular and genetic dissection of cardiogenesis

Christina V. Theodoris(link is external)           
Gene Regulatory Networks in Cardiovascular Disease

Geoffrey H. Tison(link is external)                  
Cardiovascular disease phenotyping and prediction, machine learning

Zian Tseng(link is external)
Heart rhythm

Vasanth Vedantham(link is external)           
Heart rhythm

Biao Wang(link is external)
Energy metabolism in adipocytes

Lei Wang(link is external)
Genetically encoding unnatural amino acids and biotherapeutics

Rong Wang(link is external)
Molecular programming of the vasculature in development/disease

Orion Weiner(link is external)
Cell polarity 

Balyn W. Zaro(link is external)                        
Innate immunity in human disease, therapeutic development