Isha Jain, PhD

Assistant Professor, Biochemistry and Biophysics
Address: 
35 Medical Center Way, Rm 1035
UCSF Box 3120
San Francisco, CA 94143
United States
Faculty Type: 
Affiliate Faculty
Publications: 

HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity.(link is external)

Cell

Blume SY, Garg A, Martí-Mateos Y, Midha AD, Chew BTL, Lin B, Yu C, Dick R, Lee PS, Situ E, Sarwaikar R, Green E, Ramanan V, Grotenbreg G, Hoek M, Sinz C, Jain IH

The single-molecule accessibility landscape of newly replicated mammalian chromatin.(link is external)

Cell

Ostrowski MS, Yang MG, McNally CP, Abdulhay NJ, Wang S, Renduchintala K, Irkliyenko I, Biran A, Chew BTL, Midha AD, Wong EV, Sandoval J, Jain IH, Groth A, Nora EP, Goodarzi H, Ramani V

In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.(link is external)

Science advances

Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH

Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.(link is external)

Molecular cell

Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH

Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.(link is external)

Cell metabolism

Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.(link is external)

Cancer discovery

Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM

Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells.(link is external)

Science (New York, N.Y.)

Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J

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