Allison Xu, PhD

Professor

M_Diabetes Center

+1 415 476-2807

Faculty Type

Affiliate Faculty

Research Interests: Hypothalamic regulation of energy balance, obesity and type 2 diabetes Summary: Our lab's major research focus is to understand the mechanisms by which energy balance is regulated. We use a combination of mouse genetics, whole body physiology and real time imaging approaches to elucidate the function of specific hypothalamic neurons and how they integrate peripheral metabolic signals under distinct physiologic conditions.

Publications

Identification of AgRP cells in the murine hindbrain that drive feeding.

Molecular metabolism

Bachor TP, Hwang E, Yulyaningsih E, Attal K, Mifsud F, Pham V, Vagena E, Huarcaya R, Valdearcos M, Vaisse C, Williams KW, Emmerson PJ, Xu AW

Modulation of foraging-like behaviors by cholesterol-FGF19 axis.

Cell & bioscience

Huang A, Maier MT, Vagena E, Xu AW

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis.

Science signaling

Vagena E, Crneta J, Engström P, He L, Yulyaningsih E, Korpel NL, Cheang RT, Bachor TP, Huang A, Michel G, Attal K, Berrios DI, Valdearcos M, Koliwad SK, Olson DP, Yi CX, Xu AW

A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.

Molecular metabolism

Nelson NG, Wu L, Maier MT, Lam D, Cheang R, Alba D, Huang A, Neumann DA, Hill T, Vagena E, Barsh GS, Medina MW, Krauss RM, Koliwad SK, Xu AW

Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking.

American journal of physiology. Endocrinology and metabolism

Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW

Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.

Endocrinology

Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW

Hypothalamic Sensing of Bile Acids, a Gut Feeling.

Trends in endocrinology and metabolism: TEM

Xu AW

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Cell reports

Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW

Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis.

International journal of molecular sciences

Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y

Leptin potentiates astrogenesis in the developing hypothalamus.

Molecular metabolism

Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance.

Proceedings of the National Academy of Sciences of the United States of America

Olofsson LE, Unger EK, Cheung CC, Xu AW

Metabolic transceivers: in tune with the central melanocortin system.

Trends in endocrinology and metabolism: TEM

Warne JP, Xu AW

AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice.

Endocrinology

Newton AJ, Hess S, Paeger L, Vogt MC, Fleming Lascano J, Nillni EA, Brüning JC, Kloppenburg P, Xu AW

De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pierce AA, Xu AW

Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

Diabetes

Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG, Xu AW

Functional role of c-Jun-N-terminal kinase in feeding regulation.

Endocrinology

Unger EK, Piper ML, Olofsson LE, Xu AW

Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake.

Proceedings of the National Academy of Sciences of the United States of America

Olofsson LE, Pierce AA, Xu AW

Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons.

Molecular endocrinology (Baltimore, Md.)

Piper ML, Unger EK, Myers MG, Xu AW

https://profiles.ucsf.edu/allison.xu

Address

513 Parnassus Avenue, MSB, Rm 1212A
UCSF Box 0534
San Francisco, CA 94143
United States