Anthony Shum, MD

Professor, Medicine
Research Interests: 
Autoimmunity, cGAS-STING signaling, inborn errors of immunity, ILD

Research Summary:
The Shum lab is interested in understanding the immune mechanisms that lead to lung inflammation and fibrosis in patients with autoimmune disorders. Through human and mouse studies, we seek to define the critical factors that lead to autoimmune lung disease in order to speed the development of diagnostic tests and treatments for patients.

Address: 
555 Mission Bay Blvd South, Rm 252H
UCSF Box 3118
San Francisco, CA 94158
United States
Faculty Type: 
Core CVRI Faculty
Publications: 

The common HAQ STING allele prevents clinical penetrance of COPA syndrome.(link is external)

The Journal of experimental medicine

Simchoni N, Koide S, Likhite M, Kuchitsu Y, Kadirvel S, Law CS, Elicker BM, Kurra S, Wong MM, Yuan B, Grossi A, Laxer RM, Volpi S, Dissanayake D, Taguchi T, Beck DB, Vogel TP, Shum AK

Phage Immunoprecipitation-Sequencing Reveals CDHR5 Autoantibodies in Select Patients With Interstitial Lung Disease.(link is external)

ACR open rheumatology

Upadhyay V, Yoon YM, Vazquez SE, Velez TE, Jones KD, Lee CT, Law CS, Wolters PJ, Lee S, Yang MM, Farrand E, Noth I, Strek ME, Anderson MS, DeRisi JL, Sperling AI, Shum AK

Twenty-year-old patient with polyarthritis since childhood showing cysts and ground glass attenuation on HRCT.(link is external)

Thorax

Fagundes MDC, Bianco T, Nunes DP, Ostroski TKD, Bridi GDP, Kawassaki AM, Barbas CSV, Mendonça LO, Barros SF, Kalil J, Shum AK, Escuissato DL

Activated STING in the thymus alters T cell development and selection leading to autoimmunity.(link is external)

bioRxiv : the preprint server for biology

Deng Z, Law CS, Kurra S, Simchoni N, Shum AK

Pathogenic COPA mutations decrease binding of dilysine motifs through allosteric effects.

Biophysical Journal

Anna Pavlova, Sasthi C. Mandal, Noa Simchoni, Christopher S. Law, Atanu Acharya, Anthony K. Shum, James C. Gumbart

COPA Syndrome from Diagnosis to Treatment: A Clinician's Guide.(link is external)

Rheumatic diseases clinics of North America

Simchoni N, Vogel TP, Shum AK

Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies.(link is external)

medRxiv : the preprint server for health sciences

Yoon YM, Velez TE, Upadhyay V, Vazquez SE, Lee CT, Selvan KC, Law CS, Blaine KM, Hollinger MK, Decker DC, Clark MR, Strek ME, Guzy RD, Adegunsoye A, Noth I, Wolters PJ, Anderson M, DeRisi JL, Shum AK, Sperling AI

PhIP-Seq uncovers novel autoantibodies and unique endotypes in interstitial lung disease.(link is external)

bioRxiv : the preprint server for biology

Upadhyay V, Yoon YM, Vazquez SE, Velez TE, Jones KD, Lee CT, Law CS, Wolters PJ, Lee S, Yang MM, Farrand E, Noth I, Strek ME, Anderson M, DeRisi J, Sperling AI, Shum AK

Interstitial lung disease patients exhibit augmented germinal center responses in lung lymph nodes and increased serum reactivities to novel autoantigens.

The Journal of Immunology

Young me Yoon, Tania Velez, Vaibhav Upadhyay, Sara Vazquez, Cathryn T Lee, Kelly Blaine, Donna Decker, Robert Guzy, Ayodeji Adegunsoye, Mary Strek, Imre Noth, Mark S Anderson, Joseph DeRisi, Anthony Shum, Anne I Sperling

COPA Syndrome (Ala239Pro) Presenting with Isolated Follicular Bronchiolitis in Early Childhood: Case Report.(link is external)

Journal of clinical immunology

Psarianos P, Kwan JYY, Dell S, Wee WB, Rey-McIntyre K, Chen H, Dissanayake D, Laxer RM, Shum A, Liu FF, Yip KW

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