
Assistant Professor
Cardiology
Email
CLINICAL INTERESTS: Dr. Padmanabhan is a cardiologist specializing in general cardiology. His specific interests include preventive cardiology, lamin A/C gene (LMNA) associated cardiomyopathies, and right heart disease in athletes.
RESEARCH INTERESTS: Dr. Padmanabhan’s research focuses on understanding the gene-regulatory and epigenetic pathways that govern cell fate decisions during early cardiac development and cell state transitions in the pathophysiology of heart failure.
Faculty Type
Core CVRI Faculty
Publications
Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery.
bioRxiv : the preprint server for biology
ALPK3 Heterozygous Truncating Variants Cause Late-Onset Hypertrophic Cardiomyopathy With Frequent Apical Involvement and Apical Aneurysm.
Circulation. Genomic and precision medicine
Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart.
medRxiv : the preprint server for health sciences
Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias.
JACC. Clinical electrophysiology
Automated Assessment of Right Atrial Pressure From Ultrasound Videos Using Machine Learning.
JACC. Advances
Single-nucleus RNA/ATAC-seq in early-stage HCM models predicts SWI/SNF-activation in mutant-myocytes, and allele-specific differences in fibroblasts.
bioRxiv : the preprint server for biology
A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.
Nature Cardiovascular Research
Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes.
Nature Cardiovascular Research
Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.
bioRxiv : the preprint server for biology
Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
Science translational medicine
Targeting transcription in heart failure via CDK7/12/13 inhibition.
Nature communications
Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation.
Nature genetics
Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro.
Cell systems
Drugging transcription in heart failure.
The Journal of physiology
Epigenetic therapies in heart failure.
Journal of molecular and cellular cardiology
A Wide Complex Tachycardia in a Woman During Exercise: Did She Tread Into Dangerous Territory?
JAMA internal medicine
Unusual transcription factor protects against heart failure.
Science (New York, N.Y.)
Electrical Alternans in Disguise-A Curious Case of Atrial Flutter.
JAMA internal medicine
Not Your Typical ST-Elevation Myocardial Infarction.
JAMA internal medicine
Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform.
Circulation. Heart failure
HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts.
Science (New York, N.Y.)
Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
Nature communications
Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production.
Proceedings (Baylor University. Medical Center)
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
Development (Cambridge, England)
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.
Disease models & mechanisms
Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.
Development (Cambridge, England)
Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.
Human molecular genetics
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Nature
Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining.
Circulation. Cardiovascular imaging
Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions.
Developmental biology
Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.
Proceedings of the National Academy of Sciences of the United States of America
Investigating magnetically aligned phospholipid bilayers with various lanthanide ions for X-band spin-label EPR studies.
Biochimica et biophysica acta
Magnetically aligned phospholipid bilayers at the parallel and perpendicular orientations for X-band spin-label EPR studies.
Journal of the American Chemical Society
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