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Arun Padmanabhan, MD, PhD

Assistant Professor
Cardiology
Address: 
555 Mission Bay Blvd South, Rm 352W
UCSF Box 3120
San Francisco, CA 94158
United States
Email: 
[email protected]
UCSF Profiles

CLINICAL INTERESTS: Dr. Padmanabhan is a cardiologist specializing in general cardiology. His specific interests include preventive cardiology, lamin A/C gene (LMNA) associated cardiomyopathies, and right heart disease in athletes.

RESEARCH INTERESTS: Dr. Padmanabhan’s research focuses on understanding the gene-regulatory and epigenetic pathways that govern cell fate decisions during early cardiac development and cell state transitions in the pathophysiology of heart failure.

Publications: 

Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart.

medRxiv : the preprint server for health sciences

Ma XR, Conley SD, Kosicki M, Bredikhin D, Cui R, Tran S, Sheth MU, Qiu WL, Chen S, Kundu S, Kang HY, Amgalan D, Munger CJ, Duan L, Dang K, Rubio OM, Kany S, Zamirpour S, DePaolo J, Padmanabhan A, Birth Defects Research Laboratory, Olgin J, Damrauer S, Andersson R, Gu M, Priest JR, Quertermous T, Qiu X, Rabinovitch M, Visel A, Pennacchio L, Kundaje A, Glass IA, Gifford CA, Pirruccello JP, Goodyer WR, Engreitz JM

Chromatin remodelling drives immune cell-fibroblast communication in heart failure.

Nature

Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Pelonero A, Lee CY, Sadagopan N, Huang Y, Auclair K, Zhu A, An Y, Ekstrand CA, Martinez C, Teran BG, Flanigan WR, Kim CK, Lumbao-Conradson K, Gardner Z, Li L, Costa MW, Jain R, Charo I, Combes AJ, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D

Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias.

JACC. Clinical electrophysiology

Caudal A, Liu Y, Pang PD, Maison DP, Nakasuka K, Feng J, Schwarzer-Sperber HS, Schwarzer R, Moffatt E, Henrich TJ, Padmanabhan A, Connolly AJ, Wu JC, Tseng ZH

Single-nucleus RNA/ATAC-seq in early-stage HCM models predicts SWI/SNF-activation in mutant-myocytes, and allele-specific differences in fibroblasts.

bioRxiv : the preprint server for biology

Thottakara T, Padmanabhan A, Tanriverdi T, Thambidurai T, Diaz-Rg JA, Amonkar SR, Olgin JE, Long CS, Roselle Abraham M

A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.

Nature Cardiovascular Research

Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU, Jain M, Haldar SM, Srivastava D, Jain R

Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes.

Nature Cardiovascular Research

Nishino T, Ranade SS, Pelonero A, van Soldt BJ, Ye L, Alexanian M, Koback F, Huang Y, Sadagopan N, Lam A, Zholudeva LV, Li F, Padmanabhan A, Thomas R, van Bemmel JG, Gifford CA, Costa MW, Srivastava D

Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture.

Bio-protocol

Chorba JS, Xia VQ, Smith GA, Padmanabhan A

Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.

bioRxiv : the preprint server for biology

Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Teran BG, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D

Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.

Science translational medicine

Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS

Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.

Circulation

Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D

Targeting transcription in heart failure via CDK7/12/13 inhibition.

Nature communications

Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM

Transcription factor protein interactomes reveal genetic determinants in heart disease.

Cell

Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D

Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation.

Nature genetics

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R

BRD4 orchestrates genome folding to promote neural crest differentiation.

Nature genetics

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R

Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro.

Cell systems

Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Pérez-Bermejo JA, Padmanabhan A, Yang W, Jain R, Raj A

A transcriptional switch governs fibroblast activation in heart disease.

Nature

Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.

Circulation

Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D

Drugging transcription in heart failure.

The Journal of physiology

Padmanabhan A, Haldar SM

Epigenetic therapies in heart failure.

Journal of molecular and cellular cardiology

Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM

A Wide Complex Tachycardia in a Woman During Exercise: Did She Tread Into Dangerous Territory?

JAMA internal medicine

Muniyappa A, Padmanabhan A, Goldschlager N

Unusual transcription factor protects against heart failure.

Science (New York, N.Y.)

Padmanabhan A, Haldar SM

Electrical Alternans in Disguise-A Curious Case of Atrial Flutter.

JAMA internal medicine

Cedarbaum ER, Padmanabhan A, Goldschlager N

Not Your Typical ST-Elevation Myocardial Infarction.

JAMA internal medicine

Morehead-Gee A, Padmanabhan A, Goldschlager N

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.

eLife

Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA

HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts.

Science (New York, N.Y.)

Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA

Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.

Nature communications

Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BLM, Epstein JA

Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production.

Proceedings (Baylor University. Medical Center)

Vaduganathan M, Nagarur A, Kerr DA, Lauter KB, Padmanabhan A, Raghavan S, Pallais JC, Fenves AZ

Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.

Development (Cambridge, England)

Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.

Disease models & mechanisms

Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT

Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.

Development (Cambridge, England)

Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, Wolfe SA

Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.

Human molecular genetics

Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.

Nature

Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VM, Van Deerlin VM, Bonini NM, Gitler AD

Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining.

Circulation. Cardiovascular imaging

Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA

Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions.

Developmental biology

Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA

Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.

Proceedings of the National Academy of Sciences of the United States of America

Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA

Investigating magnetically aligned phospholipid bilayers with various lanthanide ions for X-band spin-label EPR studies.

Biochimica et biophysica acta

Caporini MA, Padmanabhan A, Cardon TB, Lorigan GA

Magnetically aligned phospholipid bilayers at the parallel and perpendicular orientations for X-band spin-label EPR studies.

Journal of the American Chemical Society

Cardon TB, Tiburu EK, Padmanabhan A, Howard KP, Lorigan GA

Faculty Type: 
Core CVRI Faculty