Balyn Zaro, PhD

Assistant Professor

Pharmaceutical Chemistry

Address:

555 & 535 Mission Bay Blvd Sou, Rm 452G

San Francisco, CA 94158

United States

Phone:

+1 415 514-9219

Email:

[email protected]

UCSF Profiles

Research Interests:

Macrophage phagocytosis, covalent inhibitor development

Research Summary:
Our lab takes a chemical biology and proteomics approach to optimizing drug selectivity and studying the immune system and blood formation. We aim to profile how different types of cells metabolize drugs in order to develop more-selective therapeutics and are interested in identifying targets critical for modulating the innate immune response during cancer and infection.

Publications:

Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal.

Proceedings of the National Academy of Sciences of the United States of America

Banuelos A, Baez M, Zhang A, Yilmaz L, Kasberg W, Volk R, Georgeos N, Koren-Sedova E, Le U, Burden AT, Marjon KD, Lippincott-Schwartz J, Zaro BW, Weissman IL

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein.

Nature biotechnology

George BM, Eleftheriou M, Yankova E, Perr J, Chai P, Nestola G, Almahayni K, Evans S, Damaskou A, Hemberger H, Lebedenko CG, Rak J, Yu Q, Bapcum E, Russell J, Bagri J, Volk RF, Spiekermann M, Stone RM, Giotopoulos G, Huntly BJP, Baxter J, Camargo F, Liu J, Zaro BW, Vassiliou GS, Möckl L, de la Rosa J, Flynn RA, Tzelepis K

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry.

Cell

Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA

C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin.

bioRxiv : the preprint server for biology

Mella J, Volk R, Zaro B, Buchwalter A

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology.

bioRxiv : the preprint server for biology

Boucher M, Banerjee S, Joshi M, Wei A, Huang M, Lei S, Ciranni M, Condon A, Langen A, Goddard T, Caradonna I, Goranov A, Homer C, Mortensen Y, Petnic S, Reilly M, Xiong Y, Susa K, Pastore VP, Zaro B, Madhani H

O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone.

Protein science : a publication of the Protein Society

Javed A, Johnson OT, Balana AT, Volk RF, Langen A, Ahn BS, Zaro BW, Gestwicki JE, Pratt MR

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi.

bioRxiv : the preprint server for biology

Tal MC, Hansen PS, Ogasawara HA, Feng Q, Volk RF, Lee B, Casebeer SE, Blacker GS, Shoham M, Galloway SD, Sapiro AL, Hayes B, Torrez Dulgeroff LB, Raveh T, Pothineni VR, Potula HS, Rajadas J, Bastounis EE, Chou S, Robinson WH, Coburn J, Weissman IL, Zaro BW

Correction to "Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification".

Journal of the American Chemical Society

Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission.

eLife

Sapiro AL, Hayes BM, Volk RF, Zhang JY, Brooks DM, Martyn C, Radkov A, Zhao Z, Kinnersley M, Secor PR, Zaro BW, Chou S

EMC chaperone-CaV structure reveals an ion channel assembly intermediate.

Nature

Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.

Cell reports

Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K

Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions.

PLoS biology

Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT

Secreted fungal virulence effector triggers allergic inflammation via TLR4.

Nature

Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD

Improved Electrophile Design for Exquisite Covalent Molecule Selectivity.

ACS chemical biology

Montaño JL, Wang BJ, Volk RF, Warrington SE, Garda VG, Hofmann KL, Chen LC, Zaro BW

Proteomic characterization of phagocytic primary human monocyte-derived macrophages.

RSC chemical biology

Volk RF, Montaño JL, Warrington SE, Hofmann KL, Zaro BW

Refinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity.

Tetrahedron letters

Bouffard E, Zaro BW, Dix MM, Cravatt B, Wong CH

Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells.

eLife

Zaro BW, Noh JJ, Mascetti VL, Demeter J, George B, Zukowska M, Gulati GS, Sinha R, Flynn RA, Banuelos A, Zhang A, Wilkinson AC, Jackson P, Weissman IL