Home > People > Balyn Zaro, PhD

Balyn Zaro, PhD

Assistant Professor
Pharmaceutical Chemistry
Address: 
555 Mission Bay Blvd South, Rm 452G
San Francisco, CA 94158
United States
Phone: 
+1 415 514-9219
Research Interests: 
Macrophage phagocytosis, covalent inhibitor development

Research Summary:
Our lab takes a chemical biology and proteomics approach to optimizing drug selectivity and studying the immune system and blood formation. We aim to profile how different types of cells metabolize drugs in order to develop more-selective therapeutics and are interested in identifying targets critical for modulating the innate immune response during cancer and infection.

Publications: 

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry.

Cell

Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology.

bioRxiv : the preprint server for biology

Boucher M, Banerjee S, Joshi M, Wei A, Huang M, Lei S, Ciranni M, Condon A, Langen A, Goddard T, Caradonna I, Goranov A, Homer C, Mortensen Y, Petnic S, Reilly M, Xiong Y, Susa K, Pastore VP, Zaro B, Madhani H

O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone.

Protein science : a publication of the Protein Society

Javed A, Johnson OT, Balana AT, Volk RF, Langen A, Ahn BS, Zaro BW, Gestwicki JE, Pratt MR

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi.

bioRxiv : the preprint server for biology

Tal MC, Hansen PS, Ogasawara HA, Feng Q, Volk RF, Lee B, Casebeer SE, Blacker GS, Shoham M, Galloway SD, Sapiro AL, Hayes B, Torrez Dulgeroff LB, Raveh T, Pothineni VR, Potula HS, Rajadas J, Bastounis EE, Chou S, Robinson WH, Coburn J, Weissman IL, Zaro BW

Correction to "Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification".

Journal of the American Chemical Society

Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission.

eLife

Sapiro AL, Hayes BM, Volk RF, Zhang JY, Brooks DM, Martyn C, Radkov A, Zhao Z, Kinnersley M, Secor PR, Zaro BW, Chou S

EMC chaperone-CaV structure reveals an ion channel assembly intermediate.

Nature

Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.

Cell reports

Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K

Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions.

PLoS biology

Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT

Secreted fungal virulence effector triggers allergic inflammation via TLR4.

Nature

Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD

Improved Electrophile Design for Exquisite Covalent Molecule Selectivity.

ACS chemical biology

Montaño JL, Wang BJ, Volk RF, Warrington SE, Garda VG, Hofmann KL, Chen LC, Zaro BW

Proteomic characterization of phagocytic primary human monocyte-derived macrophages.

RSC chemical biology

Volk RF, Montaño JL, Warrington SE, Hofmann KL, Zaro BW

Refinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity.

Tetrahedron letters

Bouffard E, Zaro BW, Dix MM, Cravatt B, Wong CH

Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells.

eLife

Zaro BW, Noh JJ, Mascetti VL, Demeter J, George B, Zukowska M, Gulati GS, Sinha R, Flynn RA, Banuelos A, Zhang A, Wilkinson AC, Jackson P, Weissman IL

Metabolic Labeling for the Visualization and Identification of Potentially O-GlcNAc-Modified Proteins.

Current protocols in chemical biology

Pedowitz NJ, Zaro BW, Pratt MR

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.

Nature

Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL

The Proteome-Wide Potential for Reversible Covalency at Cysteine.

Angewandte Chemie (International ed. in English)

Senkane K, Vinogradova EV, Suciu RM, Crowley VM, Zaro BW, Bradshaw JM, Brameld KA, Cravatt BF

Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex.

Journal of immunology (Baltimore, Md. : 1950)

Zaro BW, Vinogradova EV, Lazar DC, Blewett MM, Suciu RM, Takaya J, Studer S, de la Torre JC, Casanova JL, Cravatt BF, Teijaro JR

Azide- and Alkyne-Bearing Metabolic Chemical Reporters of Glycosylation Show Structure-Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway.

Chembiochem : a European journal of chemical biology

Walter LA, Batt AR, Darabedian N, Zaro BW, Pratt MR

The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.

Journal of the American Chemical Society

Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR

Metabolic Chemical Reporters of Glycans Exhibit Cell-Type-Selective Metabolism and Glycoprotein Labeling.

Chembiochem : a European journal of chemical biology

Batt AR, Zaro BW, Navarro MX, Pratt MR

Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors.

Journal of the American Chemical Society

Zaro BW, Whitby LR, Lum KM, Cravatt BF

Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells.

Science signaling

Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease.

Nature chemistry

Marotta NP, Lin YH, Lewis YE, Ambroso MR, Zaro BW, Roth MT, Arnold DB, Langen R, Pratt MR

Chemoproteomics reveals Toll-like receptor fatty acylation.

BMC biology

Chesarino NM, Hach JC, Chen JL, Zaro BW, Rajaram MV, Turner J, Schlesinger LS, Pratt MR, Hang HC, Yount JS

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification.

Journal of the American Chemical Society

Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR

An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells.

Journal of the American Chemical Society

Bateman LA, Zaro BW, Miller SM, Pratt MR

Incorporation of unnatural sugars for the identification of glycoproteins.

Methods in molecular biology (Clifton, N.J.)

Zaro BW, Hang HC, Pratt MR

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1.

Proceedings of the National Academy of Sciences of the United States of America

Zaro BW, Yang YY, Hang HC, Pratt MR

Robust in-gel fluorescence detection of mucin-type O-linked glycosylation.

Bioorganic & medicinal chemistry letters

Zaro BW, Bateman LA, Pratt MR

Precise control of protein concentration in living cells.

Angewandte Chemie (International ed. in English)

Lau HD, Yaegashi J, Zaro BW, Pratt MR

Faculty Type: 
Core CVRI Faculty