Balyn Zaro, PhD

Assistant Professor, Pharmaceutical Chemistry
UCSF Profiles(link is external)
Research Interests: 
Macrophage phagocytosis, covalent inhibitor development

Research Summary:
Our lab takes a chemical biology and proteomics approach to optimizing drug selectivity and studying the immune system and blood formation. We aim to profile how different types of cells metabolize drugs in order to develop more-selective therapeutics and are interested in identifying targets critical for modulating the innate immune response during cancer and infection.

Address: 
555 & 535 Mission Bay Blvd Sou, Rm 452G
San Francisco, CA 94158
United States
Phone: 
+1 415 514-9219
Email: 
balyn.zaro@ucsf.edu
Faculty Type: 
Core CVRI Faculty
Publications: 

Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal.(link is external)

Proceedings of the National Academy of Sciences of the United States of America

Banuelos A, Baez M, Zhang A, Yilmaz L, Kasberg W, Volk R, Georgeos N, Koren-Sedova E, Le U, Burden AT, Marjon KD, Lippincott-Schwartz J, Zaro BW, Weissman IL

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein.(link is external)

Nature biotechnology

George BM, Eleftheriou M, Yankova E, Perr J, Chai P, Nestola G, Almahayni K, Evans S, Damaskou A, Hemberger H, Lebedenko CG, Rak J, Yu Q, Bapcum E, Russell J, Bagri J, Volk RF, Spiekermann M, Stone RM, Giotopoulos G, Huntly BJP, Baxter J, Camargo F, Liu J, Zaro BW, Vassiliou GS, Möckl L, de la Rosa J, Flynn RA, Tzelepis K

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry.(link is external)

Cell

Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology.(link is external)

bioRxiv : the preprint server for biology

Boucher M, Banerjee S, Joshi M, Wei A, Huang M, Lei S, Ciranni M, Condon A, Langen A, Goddard T, Caradonna I, Goranov A, Homer C, Mortensen Y, Petnic S, Reilly M, Xiong Y, Susa K, Pastore VP, Zaro B, Madhani H

O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone.(link is external)

Protein science : a publication of the Protein Society

Javed A, Johnson OT, Balana AT, Volk RF, Langen A, Ahn BS, Zaro BW, Gestwicki JE, Pratt MR

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi.(link is external)

bioRxiv : the preprint server for biology

Tal MC, Hansen PS, Ogasawara HA, Feng Q, Volk RF, Lee B, Casebeer SE, Blacker GS, Shoham M, Galloway SD, Sapiro AL, Hayes B, Torrez Dulgeroff LB, Raveh T, Pothineni VR, Potula HS, Rajadas J, Bastounis EE, Chou S, Robinson WH, Coburn J, Weissman IL, Zaro BW

Correction to "Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification".(link is external)

Journal of the American Chemical Society

Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission.(link is external)

eLife

Sapiro AL, Hayes BM, Volk RF, Zhang JY, Brooks DM, Martyn C, Radkov A, Zhao Z, Kinnersley M, Secor PR, Zaro BW, Chou S

EMC chaperone-CaV structure reveals an ion channel assembly intermediate.(link is external)

Nature

Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL

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