Daniel Minor, PhD

Professor, Cardiovascular Research Institute
Research Interests: 
Ion channel structure and pharmacology; toxin resistance mechanisms

Research Summary:
Membrane proteins; potassium channels, calcium channels Summary: Hearts, brains, muscles, and senses require electrical signals to function. We aim to understand the basic cellular components responsible for generating electrical activity. We focus on understanding the structure, function, and regulation of ion channels from a high-resolution viewpoint, understanding how channel mutations cause disease, and on developing new tools for controlling channel function. Video A Universal CaM Switch Changes the Kv7 Channel(link is external)

Address: 
555 & 535 Mission Bay Blvd Sou, Rm 452P
UCSF Box 3122
San Francisco, CA 94158
United States
Phone: 
+1 415 514-2836
Faculty Type: 
Core CVRI Faculty
Publications: 

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.(link is external)

Nature communications

Zakrzewska S, Nixon SA, Chen Z, Hajare HS, Park ER, Mulcahy JV, Arlinghaus KM, Neu E, Konovalov K, Provasi D, Leighfield TA, Filizola M, Du Bois J, Minor DL

Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.(link is external)

Nature structural & molecular biology

Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL

Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.(link is external)

Nature structural & molecular biology

Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL

Development of covalent chemogenetic K2P channel activators.(link is external)

Cell chemical biology

Deal PE, Lee H, Mondal A, Lolicato M, Mendonça PRF, Black H, Jang S, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site.(link is external)

bioRxiv : the preprint server for biology

Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL

Development of covalent chemogenetic K2P channel activators.(link is external)

bioRxiv : the preprint server for biology

Deal PE, Lee H, Mondal A, Lolicato M, de Mendonca PRF, Black H, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL

EMC chaperone-CaV structure reveals an ion channel assembly intermediate.(link is external)

Nature

Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL

Structural basis for CaVα2δ:gabapentin binding.(link is external)

Nature structural & molecular biology

Chen Z, Mondal A, Minor DL

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