Home > People > Daniel Minor, PhD
Dan Minor

Daniel Minor, PhD

Professor
Cardiovascular Research Institute
Address: 
555 & 535 Mission Bay Blvd Sou, Rm 452P
UCSF Box 3122
San Francisco, CA 94158
United States
Phone: 
+1 415 514-2836
Email: 
[email protected]
UCSF Profiles
Research Interests: 
Ion channel structure and pharmacology; toxin resistance mechanisms

Research Summary:
Membrane proteins; potassium channels, calcium channels Summary: Hearts, brains, muscles, and senses require electrical signals to function. We aim to understand the basic cellular components responsible for generating electrical activity. We focus on understanding the structure, function, and regulation of ion channels from a high-resolution viewpoint, understanding how channel mutations cause disease, and on developing new tools for controlling channel function. Video A Universal CaM Switch Changes the Kv7 Channel

Publications: 

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.

Nature communications

Zakrzewska S, Nixon SA, Chen Z, Hajare HS, Park ER, Mulcahy JV, Arlinghaus KM, Neu E, Konovalov K, Provasi D, Leighfield TA, Filizola M, Du Bois J, Minor DL

Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.

Nature structural & molecular biology

Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL

Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.

Nature structural & molecular biology

Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL

Development of covalent chemogenetic K2P channel activators.

Cell chemical biology

Deal PE, Lee H, Mondal A, Lolicato M, Mendonça PRF, Black H, Jang S, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site.

bioRxiv : the preprint server for biology

Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL

Development of covalent chemogenetic K2P channel activators.

bioRxiv : the preprint server for biology

Deal PE, Lee H, Mondal A, Lolicato M, de Mendonca PRF, Black H, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL

EMC chaperone-CaV structure reveals an ion channel assembly intermediate.

Nature

Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL

Structural basis for CaVα2δ:gabapentin binding.

Nature structural & molecular biology

Chen Z, Mondal A, Minor DL

Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody.

Nature communications

Morgenstern TJ, Nirwan N, Hernández-Ochoa EO, Bibollet H, Choudhury P, Laloudakis YD, Ben Johny M, Bannister RA, Schneider MF, Minor DL, Colecraft HM

Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.

Proceedings of the National Academy of Sciences of the United States of America

Chen Z, Zakrzewska S, Hajare HS, Alvarez-Buylla A, Abderemane-Ali F, Bogan M, Ramirez D, O'Connell LA, Du Bois J, Minor DL

Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.

Nature structural & molecular biology

Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL

Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation.

Cell chemical biology

MacKenzie TMG, Abderemane-Ali F, Garrison CE, Minor DL, Bois JD

Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on "toxin sponge" proteins.

The Journal of general physiology

Abderemane-Ali F, Rossen ND, Kobiela ME, Craig RA, Garrison CE, Chen Z, Colleran CM, O'Connell LA, Du Bois J, Dumbacher JP, Minor DL

Inroads into Membrane Physiology through Transport Nanomachines.

Journal of molecular biology

Stockbridge RB, Gaudet R, Grabe M, Minor DL

Ion Channels: Intersection of Structure, Function, and Pharmacology.

Journal of molecular biology

Moiseenkova-Bell V, Delemotte L, Minor DL

Structural Insights into the Mechanisms and Pharmacology of K2P Potassium Channels.

Journal of molecular biology

Natale AM, Deal PE, Minor DL

Production of K2P2.1 (TREK-1) for structural studies.

Methods in enzymology

Lee H, Lolicato M, Arrigoni C, Minor DL

Preface.

Methods in enzymology

Minor DL, Colecraft HM

Preface.

Methods in enzymology

Minor DL, Colecraft HM

Preface.

Methods in enzymology

Minor DL, Colecraft HM

The Polysite Pharmacology of TREK K2P Channels.

Advances in experimental medicine and biology

Pope L, Minor DL

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.

Science advances

Lolicato M, Natale AM, Abderemane-Ali F, Crottès D, Capponi S, Duman R, Wagner A, Rosenberg JM, Grabe M, Minor DL

SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation.

Journal of molecular biology

Kimberlin CR, Meshcheriakova A, Palty R, Raveh A, Karbat I, Reuveny E, Minor DL

Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels.

ACS chemical neuroscience

Pope L, Arrigoni C, Lou H, Bryant C, Gallardo-Godoy A, Renslo AR, Minor DL

A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function.

Neuron

Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL

Global versus local mechanisms of temperature sensing in ion channels.

Pflugers Archiv : European journal of physiology

Arrigoni C, Minor DL

Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.

Structure (London, England : 1993)

Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR

Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

Nature

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY

K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.

Nature

Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL

Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.

ACS chemical neuroscience

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL

Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.

Cell

Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL

Insights into the molecular foundations of electrical excitation.

Journal of molecular biology

Gaudet R, Roux B, Minor DL

Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.

ACS chemical neuroscience

Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL

Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.

Journal of molecular biology

Shaya D, Findeisen F, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.

ACS chemical biology

Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL

Patch-clamp characterization of the MscS-like mechanosensitive channel from Silicibacter pomeroyi.

Biophysical Journal

Petrov E, Palanivelu D, Constantine M, Rohde PR, Cox CD, Nomura T, Minor DL, Martinac B

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).

Proceedings of the National Academy of Sciences of the United States of America

Tien J, Lee HY, Minor DL, Jan YN, Jan LY

Using yeast to study potassium channel function and interactions with small molecules.

Methods in molecular biology (Clifton, N.J.)

Bagriantsev SN, Minor DL

A glutamate switch controls voltage-sensitive phosphatase function.

Nature structural & molecular biology

Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff EY, Minor DL

Chemical informatics and target identification in a zebrafish phenotypic screen.

Nature chemical biology

Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL, Roth BL, Peterson RT, Shoichet BK

Multiple modalities converge on a common gate to control K2P channel function.

The EMBO journal

Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL

Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.

Proceedings of the National Academy of Sciences of the United States of America

Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, Brüggemann A, Minor DL

Calmodulin overexpression does not alter Cav1.2 function or oligomerization state.

Channels (Austin, Tex.)

Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

The EMBO journal

Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL

Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.

Nature chemical biology

Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff EY

Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.

PloS one

Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL

2007 annual progress report synopsis of the Center for Structures of Membrane Proteins.

Journal of structural and functional genomics

Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W

A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms.

Protein science : a publication of the Protein Society

Hammon J, Palanivelu DV, Chen J, Patel C, Minor DL

Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation.

Structure (London, England : 1993)

Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL

Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting.

Proceedings of the National Academy of Sciences of the United States of America

Balss J, Papatheodorou P, Mehmel M, Baumeister D, Hertel B, Delaroque N, Chatelain FC, Minor DL, Van Etten JL, Rassow J, Moroni A, Thiel G

Structural insight into KCNQ (Kv7) channel assembly and channelopathy.

Neuron

Howard RJ, Clark KA, Holton JM, Minor DL

Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.

Nature structural & molecular biology

Pioletti M, Findeisen F, Hura GL, Minor DL

Wanting contact: how to pick up a channel.

Nature chemical biology

Minor DL

A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast.

Traffic (Copenhagen, Denmark)

Michelsen K, Mrowiec T, Duderstadt KE, Frey S, Minor DL, Mayer MP, Schwappach B

A sensitive channel family replete with sense and motion.

Nature structural & molecular biology

Minor DL

The pore helix dipole has a minor role in inward rectifier channel function.

Neuron

Chatelain FC, Alagem N, Xu Q, Pancaroglu R, Reuveny E, Minor DL

Bend to open?

Structure (London, England : 1993)

Minor DL

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

Molecular cell

Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA

Consensus-derived structural determinants of the ankyrin repeat motif.

Proceedings of the National Academy of Sciences of the United States of America

Mosavi LK, Minor DL, Peng ZY

Websites: 
https://scvrb-core.ucsf.edu/~dminor/index.html
Faculty Type: 
Core CVRI Faculty