Professor
Medicine
Email
+1 415 502-4326
Faculty Type
Affiliate Faculty
Research Interests: Epithelial biology as it relates to cardiovasculare function: hypertension, fluid and electrolyte regulation. Summary:
Publications
Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium.
Journal of the American Society of Nephrology : JASN
Correction: The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
Cell death & disease
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon.
Nature genetics
A Novel Function of FOXO4 and mTORC2 for Regulation of Kidney Gluconeogenesis.
Journal of the American Society of Nephrology
Role of mTORC2 in Aldosterone-Independent Potassium Regulation: Resolution of the Aldosterone Paradox.
Journal of the American Society of Nephrology
Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity.
Pflugers Archiv : European journal of physiology
Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium.
bioRxiv : the preprint server for biology
Aldosterone-independent regulation of K+ secretion in the distal nephron.
Current opinion in nephrology and hypertension
High Potassium Suppresses Glycosuria and Gluconeogenesis in Tubule-specific mTORC2 Knockout Mice.
Physiology
Chloride-Induced Monomer to Dimer Transition Controls WNK1 Scaffold Activity.
Journal of the American Society of Nephrology
Critical Role of mTORC2 in Maintaining Sodium and Potassium Balance: Implications for Aldosterone-Independent Regulation of Epithelial Sodium Channel (ENaC) in the Distal Nephron.
Journal of the American Society of Nephrology
High Potassium Suppresses Glycosuria in Tubule-Specific mTORC2 Knockout Mice.
Journal of the American Society of Nephrology
mTORC2 Coordinates Renal Gluconeogenesis and Glucose Reabsorption.
Journal of the American Society of Nephrology
Site-specific activity of mTORC2 in regulating renal K+ secretion to maintain ion homeostasis.
Physiology
Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.
Journal of the American Society of Nephrology : JASN
An EU task force to assess the burden of rare diseases.
Nature medicine
WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.
Journal of cell science
Glycosuria in Tubule-Specific mTORC2 Knockout Mice Resolves on a High Potassium Diet.
Journal of the American Society of Nephrology
Regulation of SGK1 Phosphorylation and Activity by mTORC2.
Journal of the American Society of Nephrology
WNK1 Is a Chloride-Sensing Scaffold That Potently Regulates mTORC2 Activity and ENaC.
Journal of the American Society of Nephrology
Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
Journal of the Endocrine Society
Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
The Journal of biological chemistry
Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.
Pflugers Archiv : European journal of physiology
The IDeaS initiative: pilot study to assess the impact of rare diseases on patients and healthcare systems.
Orphanet journal of rare diseases
Hyperpolarized MRI Detection of Dapagliflozin Effect on Gluconeogenesis in Live Animals: Proof of Principle.
Journal of the American Society of Nephrology
Role of WNK1 and WNK4 in Sensing Extracellular Potassium in Principal Cells to Modulate mTORC2-Dependent Activation of Epithelial Sodium Channel.
Journal of the American Society of Nephrology
Role of mTORC2/SGK1 Signaling in Rapid Response to Acute K Load to Maintain K+ Homeostasis.
Journal of the American Society of Nephrology
Structural Determinants of mTORC2 Substrate Specificity and SGK1 Phosphorylation Revealed by Cryogenic Electron Microscopy.
Journal of the American Society of Nephrology
mTORC2 Is Essential for Sodium-Glucose Cotransporter 2.
Journal of the American Society of Nephrology
Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.
The Journal of biological chemistry
Building a hemodiafiltration system from readily available components for continuous renal replacement therapy under disasters and pandemics: preparing for an acute kidney injury surge during COVID-19.
Current opinion in nephrology and hypertension
Antarctic ecosystems in transition - life between stresses and opportunities.
Biological reviews of the Cambridge Philosophical Society
Bacteria in the lakes of the Tibetan Plateau and polar regions.
The Science of the total environment
Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19.
Medical hypotheses
Regulation of ENaC by aldosterone and potassium.
The FASEB Journal
Association of Urinary Plasminogen-Plasmin with Edema and Epithelial Sodium Channel Activation in Patients with Nephrotic Syndrome.
American journal of nephrology
Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt.
Journal of cell science
The mTORC2-SGK1 Signaling Module Mediates Local Sensing of Potassium in Kidney Tubule Principal Cells to Activate ENaC and Promote Potassium Secretion.
The FASEB Journal
The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
Cell death & disease
Potassium Can Regulate Its Own Excretion in Collecting Duct Cells: Role of mTORC2, SGK1 and ENaC.
The FASEB Journal
Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo.
Scientific reports
Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate.
Magnetic resonance in medicine
Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease.
Bioscience reports
Detailed Clinical Phenotype and Molecular Genetic Findings in CLN3-Associated Isolated Retinal Degeneration.
JAMA ophthalmology
Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.
Kidney international
Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.
Magnetic resonance in medicine
Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia.
Metabolic brain disease
Diagnosis of neuronal ceroid lipofuscinosis type 2 (CLN2 disease): Expert recommendations for early detection and laboratory diagnosis.
Molecular genetics and metabolism
Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver.
Magnetic resonance in medicine
Detecting Metabolism of Gluconeogenic Precursors Lactate and Pyruvate in Kidney & Liver with Hyperpolarized 13 C MRI.
The FASEB Journal
Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.
Magnetic resonance in medicine
Aerobiology Over Antarctica - A New Initiative for Atmospheric Ecology.
Frontiers in microbiology
Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.
The Journal of clinical investigation
The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy.
Human molecular genetics
Collecting duct principal cell transport processes and their regulation.
Clinical journal of the American Society of Nephrology : CJASN
Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.
American journal of physiology. Renal physiology
The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis.
Human molecular genetics
Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.
The Journal of Cell Biology
SGK3 regulates Ca(2+) entry and migration of dendritic cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
The Journal of biological chemistry
Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease.
Neuropharmacology
The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation
The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.
Molecular endocrinology (Baltimore, Md.)
Organization of the ENaC-regulatory machinery.
Critical reviews in biochemistry and molecular biology
Chapter 6 Aldosterone Regulation of Ion Transport.
Brenner and Rector\u0027s The Kidney
The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport.
Molecular and cellular endocrinology
Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.
Molecular endocrinology (Baltimore, Md.)
Altered glutamate receptor function in the cerebellum of the Ppt1-/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis.
Journal of neuroscience research
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
The Journal of biological chemistry
Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.
Kidney international
Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3(Δex7/8)-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis.
Neurochemistry international
Cardiovascular effects of melanocortins.
European journal of pharmacology
Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3.
Journal of gastroenterology
Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease.
Neuropharmacology
Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization.
The Journal of biological chemistry
Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney.
American journal of physiology. Renal physiology
Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3.
American journal of physiology. Cell physiology
Role of epithelial sodium channels and their regulators in hypertension.
The Journal of biological chemistry
Regulation of gastric acid secretion by PKB/Akt2.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel.
The Journal of biological chemistry
Akt/PKB-sensitive proximal tubular glucose and phosphate transport.
The FASEB Journal
GILZ1: a key molecular determinant of intracellular signaling specificity governing epithelial sodium transport.
The FASEB Journal
Phosphopeptide Screen Uncovers JNK1 as a Potentiator of Nedd4-2-Mediated Epithelial Na+ Channel Inhibition.
The FASEB Journal
mTOR complex-2 activates ENaC by phosphorylating SGK1.
Journal of the American Society of Nephrology : JASN
Akt2/PKBbeta-sensitive regulation of renal phosphate transport.
Acta physiologica (Oxford, England)
Regulation of renal tubular glucose reabsorption by Akt2/PKBβ.
American journal of physiology. Renal physiology
Akt2 and SGK3 are both determinants of postnatal hair follicle development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone.
Experimental physiology
Epithelial sodium channel regulated by differential composition of a signaling complex.
Proceedings of the National Academy of Sciences of the United States of America
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.
PLoS biology
Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport.
American journal of physiology. Renal physiology
Differential activities of glucocorticoid-induced leucine zipper protein isoforms.
The Journal of biological chemistry
NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions.
American journal of physiology. Renal physiology
Salt, sodium channels, and SGK1.
The Journal of clinical investigation
AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.
The Journal of biological chemistry
Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ.
American journal of physiology. Renal physiology
Renal function of gene-targeted mice lacking both SGK1 and SGK3.
American journal of physiology. Regulatory, integrative and comparative physiology
Inhibition of the Epithelial Sodium Channel by AMP-Activated Kinase Involves Modulation of Nedd4-2 Activity.
The FASEB Journal
Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse.
Behavioural brain research
A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport.
The Journal of biological chemistry
Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney.
American journal of physiology. Regulatory, integrative and comparative physiology
Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.
Molecular endocrinology (Baltimore, Md.)
Decreased intestinal glucose transport in the sgk3-knockout mouse.
Pflugers Archiv : European journal of physiology
SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.
Physiology (Bethesda, Md.)
Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3.
The Journal of physiology
Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures.
Current genetics
Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling.
Endocrinology
Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.
Molecular biology of the cell
Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides.
Brain research. Brain research protocols
Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products.
Trends in endocrinology and metabolism: TEM
Regulation of epithelial ion transport by aldosterone through changes in gene expression.
Molecular and cellular endocrinology
Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells.
Hypertension (Dallas, Tex. : 1979)
Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants.
Molecular endocrinology (Baltimore, Md.)
Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities.
Endocrinology
Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.
The Journal of clinical investigation
The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.
Pflugers Archiv : European journal of physiology
Aldosterone: its receptor, target genes, and actions.
Vitamins and hormones
SGK1 regulation of epithelial sodium transport.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.
Journal of the American Society of Nephrology : JASN
Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells.
American journal of physiology. Renal physiology
Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1.
Molecular endocrinology (Baltimore, Md.)
Hypotonic induction of SGK1 and Na+ transport in A6 cells.
American journal of physiology. Renal physiology
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.
The EMBO journal
Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors.
The Journal of biological chemistry
The role of SGK1 in hormone-regulated sodium transport.
Trends in endocrinology and metabolism: TEM
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
American journal of physiology. Renal physiology
The Serum- and Glucocorticoid-Induced Kinase Is a Physiological Mediator of Aldosterone Action*.
Endocrinology
The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action.
Endocrinology
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.
American journal of physiology. Renal physiology
Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest.
Journal of virology
A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy.
Molecular and Cellular Biology
Plasma membrane calcium pump isoform 1 gene expression is repressed by corticosterone and stress in rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms.
Kidney international
Role of SGK in mineralocorticoid-regulated sodium transport.
Kidney international
Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context.
Journal of neuroendocrinology
Regulation of the rat serotonin-1A receptor gene by corticosteroids.
The Journal of biological chemistry
Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae.
Journal of bacteriology
Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids.
Molecular and Cellular Biology
Epithelial sodium channel regulated by aldosterone-induced protein sgk.
Proceedings of the National Academy of Sciences of the United States of America
Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites.
The Journal of biological chemistry
Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists.
Proceedings of the National Academy of Sciences of the United States of America
Aldosterone responsiveness of A6 cells is restored by cloned rat mineralocorticoid receptor.
The American journal of physiology
Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity.
The Journal of biological chemistry
The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter.
Microbiology (Reading, England)
Steroid receptor transcriptional synergy is potentiated by disruption of the DNA-binding domain dimer interface.
Molecular endocrinology (Baltimore, Md.)
Steroid receptor heterodimerization demonstrated in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element.
Science (New York, N.Y.)
Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis.
The Journal of clinical investigation
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