
Research Interests: Hedgehog signaling, developmental biology, brain tumors and molecular therapeutics
More children die from brain tumors than any other type of cancer, and the most common type of brain tumor in children is medulloblastoma. Like all cancers, medulloblastoma is caused by uncontrolled cell growth. Approximately one-third of medulloblastoma cancers arise when a particular signal that tells brain cells to grow, called Hedgehog, gets stuck in the “on” position.
We are interested in uncovering exactly how Hedgehog signals tell cancer cells to grow. To do so, we are investigating how the Hedgehog pathway is activated, and how Hedgehog activation regulates the expression of other signals to influence cell growth.
Understanding how Hedgehog signals cause cancer may show us how to turn off these signals, and potentially, lead to new therapies for medulloblastoma.
Publications
Author Correction: Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy.
Glioma-neuronal circuit remodeling induces regional immunosuppression.
Genomic features underlying meningioma sex-specificity.
Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy.
IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma.
Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy.
cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.
Grade-stratified meningioma risk among individuals who are Non-Hispanic black and interactions with male sex.
Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis.
Molecular evolution of metastatic meningioma: A case report.
A generative framework for enhanced cell-type specificity in rationally designed mRNAs.
Consensus Radiation Treatment Planning Guidelines Utilizing (68)Ga-DOTATATE PET/CT for Resected Meningiomas.
RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups.
High-Grade Progression, Sarcomatous Transformation, and/or Metastasis of Pituitary Neuroendocrine Neoplasms (PitNENs): The UCSF Experience.
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.
Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy.
MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features.
The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas.
Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.
Glioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity.
Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.
Correction to: Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data.
Calcified meningiomas demonstrate equivocal grade, proliferation, and immediate surgical outcomes.
Elevated meningioma risk among individuals who are Non-Hispanic Black is strongest for grade 2-3 tumors and synergistically modified by male sex.
Response to immune checkpoint inhibition in a meningioma with DNA mismatch repair deficiency.
Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data.
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution.
Implications and interchangeability of meningioma biomarkers for clinical trials and clinical practice.
NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.
Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas.
Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas.
Adverse radiation effect versus tumor progression following stereotactic radiosurgery for brain metastases: Implications of radiologic uncertainty.
A 34-gene expression biomarker predicts meningioma outcomes and radiotherapy responses.
Epigenetic reprogramming shapes the cellular landscape of schwannoma.
Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance.
Pan-cancer copy number variant analysis identifies optimized size thresholds and co-occurrence models for individualized risk-stratification.
Epidemiology, Genetics, and DNA Methylation Grouping of Hyperostotic Meningiomas.
"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations.
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
A Prospective Registry Study of 68Ga-DOTATATE PET/CT Incorporation Into Treatment Planning of Intracranial Meningiomas.
Glioma-neuronal circuit remodeling induces regional immunosuppression.
Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.
Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.
Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis.
NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.
Correction: Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.
Radiotherapy and radiosurgery for meningiomas.
Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.
Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features.
MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features.
Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma.
Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas.
Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.
Radiotherapy for Meningioma.
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.
Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases.
Radiotherapy for meningiomas.
A case (report) for mechanistic validation of meningioma molecular therapies.
Gene expression analysis during progression of malignant meningioma compared to benign meningioma.
Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance.
Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
CDK 4/6 inhibitors for the treatment of meningioma.
Intrinsically Disordered Protein Micelles as Vehicles for Convection-Enhanced Drug Delivery to Glioblastoma Multiforme.
Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.
68Ga-DOTATATE PET: The Future of Meningioma Treatment.
Intratumor and informatic heterogeneity influence meningioma molecular classification.
Supervised machine learning algorithms demonstrate proliferation index correlates with long-term recurrence after complete resection of WHO grade I meningioma.
Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases.
Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.
A molecularly integrated grade for meningioma.
CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data.
Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors.
Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen.
Mouse models of glioblastoma for the evaluation of novel therapeutic strategies.
Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis.
Residents-as-Teachers Curriculum for Radiation Oncology: A Targeted Needs Assessment.
A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma.
Sterol regulation of developmental and oncogenic Hedgehog signaling.
Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.
Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.
A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.
Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival.
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index.
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.
DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma.
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.
Clinical Implications of Primary Cilia in Skin Cancer.
Stereotactic Body Radiation Therapy of Adrenal Metastases: A Pooled Meta-Analysis and Systematic Review of 39 Studies with 1006 Patients.
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
Preclinical models of meningioma: Cell culture and animal systems.
Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.
Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.
Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.
Clinical, radiological, and histopathological predictors for long-term prognosis after surgery for atypical meningiomas.
Reirradiation of recurrent high-grade glioma and development of prognostic scores for progression and survival.
Meningioma metastases: incidence and proposed screening paradigm.
Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma.
Preoperative Dural Contact and Recurrence Risk After Surgical Cavity Stereotactic Radiosurgery for Brain Metastases: New Evidence in Support of Consensus Guidelines.
Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma.
Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes.
Misactivation of Hedgehog signaling causes inherited and sporadic cancers.
Advances in multidisciplinary therapy for meningiomas.
The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.
Surgical outcomes after reoperation for recurrent non-skull base meningiomas.
Cilia-Associated Oxysterols Activate Smoothened.
Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers.
Clinical Applications of Quantitative 3-Dimensional MRI Analysis for Pediatric Embryonal Brain Tumors.
Surgical Outcomes, Complications, and Management Strategies for Foramen Magnum Meningiomas.
Surgical outcomes after reoperation for recurrent skull base meningiomas.
How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In.
Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy.
Petrous Face Meningiomas: Classification, Clinical Syndromes, and Surgical Outcomes.
Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation.
Salvage therapy outcomes for atypical meningioma.
Presenting Symptoms and Prognostic Factors for Symptomatic Outcomes Following Resection of Meningioma.
Hedgehog signaling drives medulloblastoma growth via CDK6.
Multiple myeloma and a mischievous pacemaker: A teaching case involving irradiation of a cardiovascular implantable electronic device.
Case-based review: pediatric medulloblastoma.
Management of Chordoma and Chondrosarcoma with Fractionated Stereotactic Radiotherapy.
Pediatric high-grade glioma: current molecular landscape and therapeutic approaches.
Surgical Resection and Interstitial Iodine-125 Brachytherapy for High-Grade Meningiomas: A 25-Year Series.
Survival after chemotherapy and stem cell transplant followed by delayed craniospinal irradiation is comparable to upfront craniospinal irradiation in pediatric embryonal brain tumor patients.
Educational Impact of a Structured Radiation Oncology Clerkship Curriculum: An Interinstitutional Comparison.
Discovery of additional brain metastases on the day of stereotactic radiosurgery: risk factors and outcomes.
Resection and brain brachytherapy with permanent iodine-125 sources for brain metastasis.
Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.
Parameters influencing local control of meningiomas treated with radiosurgery.
Meningiomas With Rhabdoid Features Lacking Other Histologic Features of Malignancy: A Study of 44 Cases and Review of the Literature.
Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.
Induction Hedgehog pathway inhibition followed by combined-modality radiotherapy for basal cell carcinoma.
S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability.
The management of central neurocytoma: radiotherapy.
Toward an improved understanding of the ionizing radiation induced DNA damage/response networks in human malignancies.
Non-Muscle Myosin IIa Heavy Chain Links Squamous-Cell Carcinoma of the Head and Neck to the DNA Damage Response.
A national radiation oncology medical student clerkship survey: didactic curricular components increase confidence in clinical competency.
Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux.
Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.
DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site.
A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.
Radiation oncology fourth-year medical student clerkships: a targeted needs assessment.
p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage.
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.
Tight junction pore and leak pathways: a dynamic duo.
MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity.
Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.
Risks of cerebrovascular events related to open heart surgery.
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