David Raleigh, PhD, MD

Associate Professor, Radiation Oncology

Research Interests: Hedgehog signaling, developmental biology, brain tumors and molecular therapeutics  

More children die from brain tumors than any other type of cancer, and the most common type of brain tumor in children is medulloblastoma. Like all cancers, medulloblastoma is caused by uncontrolled cell growth. Approximately one-third of medulloblastoma cancers arise when a particular signal that tells brain cells to grow, called Hedgehog, gets stuck in the “on” position.

We are interested in uncovering exactly how Hedgehog signals tell cancer cells to grow. To do so, we are investigating how the Hedgehog pathway is activated, and how Hedgehog activation regulates the expression of other signals to influence cell growth.

Understanding how Hedgehog signals cause cancer may show us how to turn off these signals, and potentially, lead to new therapies for medulloblastoma.

Address: 
1450 Third Street, Rm 403
UCSF Box 0520
San Francisco, CA 94158
United States
Email: 
Faculty Type: 
Affiliate Faculty
Publications: 

Glioma-neuronal circuit remodeling induces regional immunosuppression.(link is external)

Nature communications

Nejo T, Krishna S, Yamamichi A, Lakshmanachetty S, Jimenez C, Lee KY, Baker DL, Young JS, Chen T, Phyu SSS, Phung L, Gallus M, Maldonado GC, Okada K, Ogino H, Watchmaker PB, Diebold D, Choudhury A, Daniel AGS, Cadwell CR, Raleigh DR, Hervey-Jumper SL, Okada H

EANO guideline on molecular testing of meningiomas for targeted therapy selection.(link is external)

Neuro-Oncology

Sahm F, Bertero L, Brandner S, Capper D, Goldbrunner R, Jenkinson MD, Kalamarides M, Lamszus K, Albert NL, Mair MJ, Berghoff AS, Mawrin C, Wirsching HG, Maas SL, Raleigh DR, Reifenberger G, Schweizer L, Suwala AK, Tabatabai G, Tabouret E, Short S, Wen PY, Weller M, Le Rhun E, Wesseling P, van den Bent M, Preusser M

Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy.(link is external)

Nature communications

Barrios J, Porter E, Capaldi DPI, Upadhaya T, Chen WC, Perks JR, Apte A, Aristophanous M, LoCastro E, Hsu D, Stone PH, Villanueva-Meyer JE, Valdes G, Jiang F, Maddalena M, Ballangrud A, Prezelski K, Lin H, Sun JY, Aldin MAK, Chau OW, Ziemer B, Seaberg M, Sneed PK, Nakamura JL, Boreta LC, Fogh SE, Raleigh DR, Chew J, Vasudevan H, Cha S, Hess C, Fragoso R, Shultz DB, Pike L, Hervey-Jumper SL, Tsang DS, Theodosopoulos P, Cooke D, Benedict SH, Sheng K, Seuntjens J, Coolens C, Deasy J, Braunstein S, Morin O

Spatial synaptic connectivity underlies oligodendroglioma evolution and recurrence.(link is external)

Research square

Raleigh D, Mirchia K, Oten S, Picart T, Nguyen M, Ambati V, Vasudevan H, Young J, Taylor J, Krishna S, Brang D, Phillips J, Perry A, Berger M, Chang S, de Groot J, Hervey-Jumper S

IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma.(link is external)

bioRxiv : the preprint server for biology

Young JS, Cho NW, Lucas CG, Najem H, Mirchia K, Chen WC, Seo K, Zakimi N, Daggubati V, Casey-Clyde T, Nguyen MP, Chen A, Phillips JJ, Ozawa T, Aghi MK, Taylor JW, DeRisi JL, Bhaduri A, Berger MS, Heimberger AB, Butowski N, Spitzer MH, Raleigh DR

Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy.(link is external)

Neuro-Oncology

Lin K, Zou C, Hubbard A, Sengelmann S, Goudy L, Wang IC, Sharma R, Pak J, Foster K, Ozawa T, de Groot JF, Phillips J, Vasudevan HN, Raleigh DR, Marson A, Murthy N, Gilbert LA, Berger MS, Liu SJ

A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence.(link is external)

Neuro-Oncology

Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC, Raleigh DR

cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.(link is external)

Neuro-Oncology

Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A, Giannini C, Gilbert MR, Louis DN, Raleigh DR, Reifenberger G, Santagata S, Sarkar C, Zadeh G, Wesseling P, Perry A

Grade-stratified meningioma risk among individuals who are Non-Hispanic black and interactions with male sex.(link is external)

Journal of the National Cancer Institute

Walsh KM, Price M, Raleigh DR, Calabrese E, Kruchko C, Barnholtz-Sloan JS, Ostrom QT

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