Home > People > David Raleigh, PhD, MD

David Raleigh, PhD, MD

Associate Professor
Radiation Oncology
Address: 
1450 Third Street, Rm 403
UCSF Box 0520
San Francisco, CA 94158
United States
Phone: 
Email: 
UCSF Profiles

Research Interests: Hedgehog signaling, developmental biology, brain tumors and molecular therapeutics  

More children die from brain tumors than any other type of cancer, and the most common type of brain tumor in children is medulloblastoma. Like all cancers, medulloblastoma is caused by uncontrolled cell growth. Approximately one-third of medulloblastoma cancers arise when a particular signal that tells brain cells to grow, called Hedgehog, gets stuck in the “on” position.

We are interested in uncovering exactly how Hedgehog signals tell cancer cells to grow. To do so, we are investigating how the Hedgehog pathway is activated, and how Hedgehog activation regulates the expression of other signals to influence cell growth.

Understanding how Hedgehog signals cause cancer may show us how to turn off these signals, and potentially, lead to new therapies for medulloblastoma.

Publications: 

The Impact of MRI-Defined Extent of Resection Across Meningioma DNA Methylation Groups: Re-Evaluating Surgery in the Era of Meningioma Molecular Classification.

Neurosurgery

Morshed RA, Nguyen MP, Choudhury A, Al-Adli NN, Magill ST, Haddad AF, Mirchia K, Lucas CG, Theodosopoulos PV, McDermott MW, Chen WC, Raleigh DR

A generative framework for enhanced cell-type specificity in rationally designed mRNAs.

bioRxiv : the preprint server for biology

Khoroshkin M, Zinkevich A, Aristova E, Yousefi H, Lee SB, Mittmann T, Manegold K, Penzar D, Raleigh DR, Kulakovskiy IV, Goodarzi H

Consensus Radiation Treatment Planning Guidelines Utilizing (68)Ga-DOTATATE PET/CT for Resected Meningiomas.

International journal of radiation oncology, biology, physics

Perlow HK, Raleigh DR, Wang TJC, Pollom EL, Milano MT, Breen WG, Detsky J, Chang EL, Tom MC, Shiue KR, Lehrer EJ, Saeed H, Pike LRG, Lo SS, Mishra MV, Knisely JPS, Chao ST, Sahgal A, Palmer JD

RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups.

Neuro-Oncology

Leclair NK, Choudury A, Chen WC, Magill ST, McCortney K, Horbinski CM, Chen Z, Goldschmidt E, Eaton CD, Bulsara KR, Linda Bi W, Patel AJ, Sahm F, Raleigh D, Anczukow O

EANO guideline on molecular testing of meningiomas for targeted therapy selection.

Neuro-Oncology

Sahm F, Bertero L, Brandner S, Capper D, Goldbrunner R, Jenkinson MD, Kalamarides M, Lamszus K, Albert NL, Mair MJ, Berghoff AS, Mawrin C, Wirsching HG, Maas SL, Raleigh DR, Reifenberger G, Schweizer L, Suwala AK, Tabatabai G, Tabouret E, Short S, Wen PY, Weller M, Le Rhun E, Wesseling P, van den Bent M, Preusser M

Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses.

Neuro-Oncology

Lucas CG, Al-Adli NN, Young JS, Gupta R, Morshed RA, Wu J, Ravindranathan A, Shai A, Oberheim Bush NA, Taylor JW, de Groot J, Villanueva-Meyer JE, Pekmezci M, Perry A, Bollen AW, Theodosopoulos PV, Aghi MK, Chang EF, Hervey-Jumper SL, Raleigh DR, Molinaro AM, Costello JF, Diaz AA, Clarke JL, Butowski NA, Phillips JJ, Chang SM, Berger MS, Solomon DA

Grade-stratified meningioma risk among individuals who are Non-Hispanic black and interactions with male sex.

Journal of the National Cancer Institute

Walsh KM, Price M, Raleigh DR, Calabrese E, Kruchko C, Barnholtz-Sloan JS, Ostrom QT

High-Grade Progression, Sarcomatous Transformation, and/or Metastasis of Pituitary Neuroendocrine Neoplasms (PitNENs): The UCSF Experience.

Endocrine pathology

Terry M, Nguyen MP, Tang V, Guney E, Bharani KL, Dahiya S, Choutka O, Borys E, Reis G, Blevins L, Aghi MK, Kunwar S, DeGroot J, Raleigh DR, Pekmezci M, Bollen AW, Cha S, Joseph NM, Perry A

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.

Genome biology

Liu SJ, Zou C, Pak J, Morse A, Pang D, Casey-Clyde T, Borah AA, Wu D, Seo K, O'Loughlin T, Lim DA, Ozawa T, Berger MS, Kamber RA, Weiss WA, Raleigh DR, Gilbert LA

Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy.

Cancer discovery

Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Oberheim Bush NA, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR

Meningioma: International Consortium on Meningiomas (ICOM) consensus review on scientific advances & treatment paradigms for clinicians, researchers, and patients.

Neuro-Oncology

Wang JZ, Landry AP, Raleigh DR, Sahm F, Walsh KM, Goldbrunner R, Yefet LS, Tonn JC, Gui C, Ostrom QT, Barnholtz-Sloan J, Perry A, Ellenbogen Y, Hanemann CO, Jungwirth G, Jenkinson MD, Tabatabai G, Mathiesen TI, McDermott MW, Tatagiba M, la Fougère C, Maas SLN, Galldiks N, Albert NL, Brastianos PK, Ehret F, Minniti G, Lamszus K, Ricklefs FL, Schittenhelm J, Drummond KJ, Dunn IF, Pathmanaban ON, Cohen-Gadol A, Sulman EP, Tabouret E, Le Rhun E, Mawrin C, Moliterno J, Weller M, Bi WL, Gao A, Yip S, Niyazi M, International Consortium on Meningiomas (ICOM), Aldape K, Wen PY, Short S, Preusser M, Nassiri F, Zadeh G

A targeted gene expression biomarker predicts clinic low-risk meningioma recurrence.

Neuro-Oncology

Nguyen MP, Morshed RA, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Horbinski CM, Magill ST, Chen WC, Raleigh DR

MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features.

Nature communications

Eaton CD, Avalos L, Liu SJ, Chen Z, Zakimi N, Casey-Clyde T, Bisignano P, Lucas CG, Stevenson E, Choudhury A, Vasudevan HN, Magill ST, Young JS, Krogan NJ, Villanueva-Meyer JE, Swaney DL, Raleigh DR

cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.

Neuro-Oncology

Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A, Giannini C, Gilbert MR, Louis DN, Raleigh DR, Reifenberger G, Santagata S, Sarkar C, Zadeh G, Wesseling P, Perry A

Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis.

Neuro-Oncology

Mirchia K, Choudhury A, Joseph T, Birrueta JO, Phillips JJ, Bhaduri A, Crouch EE, Perry A, Raleigh DR

The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas.

Acta neuropathologica

Leclair NK, Lucas CG, Mirchia K, McCortney K, Horbinski CM, Raleigh DR, Anczukow O

Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma.

Neurosurgery

Morshed RA, Nguyen MP, Youngblood MW, Perlow HK, Lucas CG, Patel AJ, Palmer JD, Chandler JP, Theodosopoulos PV, Magill ST, Chen WC, Raleigh DR

Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.

Nature communications

Ha K, Mundt-Machado N, Bisignano P, Pinedo A, Raleigh DR, Loeb G, Reiter JF, Cao E, Delling M

Glioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity.

bioRxiv : the preprint server for biology

Fazzari E, Azizad DJ, Yu K, Ge W, Li MX, Nano PR, Kan RL, Tum HA, Tse C, Bayley NA, Haka V, Cadet D, Perryman T, Soto JA, Wick B, Raleigh DR, Crouch EE, Patel KS, Liau LM, Deneen B, Nathanson DA, Bhaduri A

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.

bioRxiv : the preprint server for biology

Casey-Clyde T, Liu SJ, Serrano JAC, Teng C, Jang YG, Vasudevan HN, Bush JO, Raleigh DR

Correction to: Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data.

Journal of neuro-oncology

Shetty A, Wang S, Khan AB, English CW, Nouri SH, Magill ST, Raleigh DR, Klisch TJ, Harmanci AO, Patel AJ, Harmanci AS

Calcified meningiomas demonstrate equivocal grade, proliferation, and immediate surgical outcomes.

World neurosurgery

Umbach G, Kanungo I, Quintana D, Choudhury A, Morshed R, Villanueva-Meyer J, Theodosopoulos P, Magill ST, McDermott M, Raleigh D, Goldschmidt E

Elevated meningioma risk among individuals who are Non-Hispanic Black is strongest for grade 2-3 tumors and synergistically modified by male sex.

medRxiv : the preprint server for health sciences

Walsh KM, Price M, Raleigh DR, Calabrese E, Kruchko C, Barnholtz-Sloan JS, Ostrom QT

Response to immune checkpoint inhibition in a meningioma with DNA mismatch repair deficiency.

Neuro-oncology advances

Nguyen MP, Almiron Bonnin D, Mirchia K, Chen WC, Goldschmidt E, Braunstein SE, Perry A, Raleigh DR, Oberheim Bush NA

Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data.

Journal of neuro-oncology

Shetty A, Wang S, Khan AB, English CW, Nouri SH, Magill ST, Raleigh DR, Klisch TJ, Harmanci AO, Patel AJ, Harmanci AS

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

Cell genomics

Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC

Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution.

Nature genetics

Lucas CG, Mirchia K, Seo K, Najem H, Chen WC, Zakimi N, Foster K, Eaton CD, Cady MA, Choudhury A, Liu SJ, Phillips JJ, Magill ST, Horbinski CM, Solomon DA, Perry A, Vasudevan HN, Heimberger AB, Raleigh DR

Implications and interchangeability of meningioma biomarkers for clinical trials and clinical practice.

Journal of neuro-oncology

Raleigh DR, Chen WC, Gondi V, Rogers L, Mehta M

NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.

Brain pathology (Zurich, Switzerland)

Eschbacher KL, Tran QT, Moskalev EA, Jenkins S, Fritchie K, Stoehr R, Caron A, Link MJ, Brown PD, Guajardo A, Brat DJ, Wu A, Santagata S, Louis DN, Brastianos PK, Kaplan AB, Alexander B, Rossi S, Ferrarese F, Raleigh DR, Nguyen MP, Gross J, Velazquez Vega J, Rodriguez F, Perry A, Martinez-Lage M, Orr BA, Haller F, Giannini C

Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas.

Acta neuropathologica

Zakimi N, Mazcko CN, Toedebusch C, Tawa G, Woolard K, LeBlanc AK, Dickinson PJ, Raleigh DR

Adverse radiation effect versus tumor progression following stereotactic radiosurgery for brain metastases: Implications of radiologic uncertainty.

Journal of neuro-oncology

Salans M, Ni L, Morin O, Ziemer B, Capaldi DPI, Raleigh DR, Vasudevan HN, Chew J, Nakamura J, Sneed PK, Boreta L, Villanueva-Meyer JE, Theodosopoulos P, Braunstein S

Epigenetic reprogramming shapes the cellular landscape of schwannoma.

Nature communications

Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez KJ, Stevenson E, Chen KH, Lien BV, Wu D, Braunstein SE, Sneed PK, Magill ST, Lim D, McDermott MW, Berger MS, Perry A, Krogan NJ, Hansen MR, Spitzer MH, Gilbert L, Theodosopoulos PV, Raleigh DR

Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance.

Nature communications

Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, Abate AR, McCormick F, Raleigh DR

Epidemiology, Genetics, and DNA Methylation Grouping of Hyperostotic Meningiomas.

Operative neurosurgery (Hagerstown, Md.)

Umbach G, Tran EB, Eaton CD, Choudhury A, Morshed R, Villanueva-Meyer JE, Theodosopoulos PV, Magill ST, McDermott MW, Raleigh DR, Goldschmidt E

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.

Acta neuropathologica

Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA

Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations.

The Journal of clinical investigation

Garcia JH, Akins EA, Jain S, Wolf KJ, Zhang J, Choudhary N, Lad M, Shukla P, Rios J, Seo K, Gill SA, Carson WH, Carette LR, Zheng AC, Raleigh DR, Kumar S, Aghi MK

Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.

Nature medicine

Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, Lam TC, Pu JK, Li LF, Leung GK, Chan JW, Perlow HK, Palmer JD, Haberler C, Berghoff AS, Preusser M, Nicolaides TP, Mawrin C, Agnihotri S, Resnick A, Rood BR, Chew J, Young JS, Boreta L, Braunstein SE, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer JE, Chandler JP, Solomon DA, Rogers CL, Pugh SL, Mehta MP, Sneed PK, Berger MS, Horbinski CM, McDermott MW, Perry A, Bi WL, Patel AJ, Sahm F, Magill ST, Raleigh DR

A Prospective Registry Study of 68Ga-DOTATATE PET/CT Incorporation Into Treatment Planning of Intracranial Meningiomas.

International journal of radiation oncology, biology, physics

Perlow HK, Nalin AP, Handley D, Gokun Y, Blakaj DM, Beyer SJ, Thomas EM, Raval RR, Boulter D, Kleefisch C, Bovi J, Chen WC, Braunstein SE, Raleigh DR, Knisely JPS, Ivanidze J, Palmer JD

Glioma-neuronal circuit remodeling induces regional immunosuppression.

bioRxiv : the preprint server for biology

Nejo T, Krishna S, Jimenez C, Yamamichi A, Young JS, Lakshmanachetty S, Chen T, Phyu SSS, Ogino H, Watchmaker P, Diebold D, Choudhury A, Daniel AGS, Raleigh DR, Hervey-Jumper SL, Okada H

Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.

Research square

Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D

Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.

JAMA network open

Vasudevan HN, Delley C, Chen WC, Mirchia K, Pan S, Shukla P, Aabedi AA, Nguyen MP, Morshed RA, Young JS, Boreta L, Fogh SE, Nakamura JL, Theodosopoulos PV, Phillips J, Hervey-Jumper SL, Daras M, Pike L, Aghi MK, Tsai K, Raleigh DR, Braunstein SE, Abate AR

Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis.

Research square

Raleigh D, Mirchia K, Choudhury A, Joseph T, Birrueta J, Phillips J, Bhaduri A, Crouch E, Perry A

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.

bioRxiv : the preprint server for biology

Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR

Correction: Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.

Acta neuropathologica

Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, Sahm F, Boutros PC, Aldape K, International Consortium on Meningiomas (ICOM), Nassiri F, Zadeh G

Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time.

Cancers

Nandoliya KR, Sadagopan NS, Thirunavu V, Houskamp EJ, Karras CL, Chaliparambil RK, Sriram N, Jamshidi P, Raleigh DR, Lukas RV, Magill ST

Radiotherapy and radiosurgery for meningiomas.

Neuro-oncology advances

Chen WC, Lucas CG, Magill ST, Rogers CL, Raleigh DR

Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.

Research square

Lucas CH, Mirchia K, Seo K, Najem H, Chen W, Zakimi N, Choudhury A, Liu SJ, Phillips J, Magill S, Horbinski C, Solomon D, Perry A, Vasudevan H, Heimberger A, Raleigh D

Glioblastoma remodelling of human neural circuits decreases survival.

Nature

Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Nava Gonzales C, Sudharshan R, Egladyous A, Almeida N, Zhang Y, Molinaro AM, Venkatesh HS, Daniel AGS, Shamardani K, Hyer J, Chang EF, Findlay A, Phillips JJ, Nagarajan S, Raleigh DR, Brang D, Monje M, Hervey-Jumper SL

Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.

Acta neuropathologica

Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, Sahm F, Boutros PC, Aldape K, International Consortium on Meningiomas (ICOM), Nassiri F, Zadeh G

Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.

Research square

Raleigh D, Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M, Bayley J, Harmanci A, Harmanci A, Klisch T, Nguyen M, Vasudevan H, McCortney K, Yu T, Bhave V, Lam TC, Pu J, Leung G, Chang J, Perlow H, Palmer J, Haberler C, Berghoff A, Preusser M, Nicolaides T, Mawrin C, Agnihotri S, Resnick A, Rood B, Chew J, Young J, Boreta L, Braunstein S, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer J, Chandler J, Solomon D, Rogers C, Pugh S, Mehta M, Sneed P, Berger M, Horbinski C, McDermott M, Perry A, Bi W, Patel A, Sahm F, Magill S

Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features.

Neuro-Oncology

Choudhury A, Chen WC, Lucas CG, Bayley JC, Harmanci AS, Maas SLN, Santagata S, Klisch T, Perry A, Bi WL, Sahm F, Patel AJ, Magill ST, Raleigh DR

MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features.

Research square

Eaton C, Avalos L, Liu SJ, Casey-Clyde T, Bisignano P, Lucas CH, Stevenson E, Choudhury A, Vasudevan H, Magill S, Krogan N, Villanueva-Meyer J, Swaney D, Raleigh D

Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma.

Acta neuropathologica

Khan AB, English CW, Chen WC, Athukuri P, Bayley JC, Brandt VL, Shetty A, Hadley CC, Choudhury A, Lu HC, Harmanci AO, Harmanci AS, Magill ST, Raleigh DR, Klisch TJ, Patel AJ

Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas.

Acta neuropathologica

Tang V, Lu R, Mirchia K, Van Ziffle J, Devine P, Lee J, Phillips JJ, Perry A, Raleigh DR, Lucas CG, Solomon DA

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.

The Journal of clinical investigation

Lee D, Gimple RC, Wu X, Prager BC, Qiu Z, Wu Q, Daggubati V, Mariappan A, Gopalakrishnan J, Sarkisian MR, Raleigh DR, Rich JN

Radiotherapy for Meningioma.

Advances in experimental medicine and biology

Susko MS, Raleigh DR

A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.

Nature cancer

Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA

Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases.

World neurosurgery

Vasudevan HN, Susko MS, Ma L, Nakamura JL, Raleigh DR, Boreta L, Fogh S, Theodosopoulos PV, McDermott MW, Tsai KK, Sneed PK, Braunstein SE

Radiotherapy for meningiomas.

Journal of neuro-oncology

Chen WC, Perlow HK, Choudhury A, Nguyen MP, Mirchia K, Youngblood MW, Lucas CG, Palmer JD, Magill ST, Raleigh DR

A case (report) for mechanistic validation of meningioma molecular therapies.

Neuro-oncology advances

Nguyen MP, Seo K, Eaton CD, Lucas CG, Chen WC, Choudhury A, Young JS, Raleigh DR

Gene expression analysis during progression of malignant meningioma compared to benign meningioma.

Journal of neurosurgery

Maier AD, Meddis A, Mirian C, Haslund-Vinding J, Bartek J, Krog SM, Nguyen TUP, Areškeviciute A, Melchior LC, Heegaard S, Kristensen BW, Munch TN, Fugleholm K, Ziebell M, Raleigh DR, Poulsen FR, Gerds TA, Litman T, Scheie D, Mathiesen T

Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance.

Proceedings of the National Academy of Sciences of the United States of America

Peng KL, Vasudevan HN, Lockney DT, Baum R, Hendrickson RC, Raleigh DR, Schmitt AM

Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.

Acta neuropathologica

Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon DA

CDK 4/6 inhibitors for the treatment of meningioma.

Frontiers in oncology

Young JS, Kidwell RL, Zheng A, Haddad AF, Aghi MK, Raleigh DR, Schulte JD, Butowski NA

Intrinsically Disordered Protein Micelles as Vehicles for Convection-Enhanced Drug Delivery to Glioblastoma Multiforme.

ACS applied bio materials

Gleason JM, Klass SH, Huang P, Ozawa T, Santos RA, Fogarty MM, Raleigh DR, Berger MS, Francis MB

Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.

Journal of neuropathology and experimental neurology

Lucas CG, Davidson CJ, Alashari M, Putnam AR, Whipple NS, Bruggers CS, Mendez JS, Cheshier SH, Walker JB, Ramani B, Cadwell CR, Sullivan DV, Lu R, Mirchia K, Van Ziffle J, Devine P, Goldschmidt E, Hervey-Jumper SL, Gupta N, Oberheim Bush NA, Raleigh DR, Bollen A, Tihan T, Pekmezci M, Solomon DA, Phillips JJ, Perry A

68Ga-DOTATATE PET: The Future of Meningioma Treatment.

International journal of radiation oncology, biology, physics

Prasad RN, Perlow HK, Bovi J, Braunstein SE, Ivanidze J, Kalapurakal JA, Kleefisch C, Knisely JPS, Mehta MP, Prevedello DM, Raleigh DR, Mishra MV, Roberge D, Rogers CL, Palmer JD

Intratumor and informatic heterogeneity influence meningioma molecular classification.

Acta neuropathologica

Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR

Supervised machine learning algorithms demonstrate proliferation index correlates with long-term recurrence after complete resection of WHO grade I meningioma.

Journal of neurosurgery

Nguyen MP, Morshed RA, Dalle Ore CL, Cummins DD, Saggi S, Chen WC, Choudhury A, Ravi A, Raleigh DR, Magill ST, McDermott MW, Theodosopoulos PV

Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases.

Journal of neurosurgery

Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.

Nature genetics

Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR

A molecularly integrated grade for meningioma.

Neuro-Oncology

Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi WL

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.

Nature communications

Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD

Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data.

Neuro-oncology advances

Hansford JR, Huang J, Endersby R, Dodgshun AJ, Li BK, Hwang E, Leary S, Gajjar A, Von Hoff K, Wells O, Wray A, Kotecha RS, Raleigh DR, Stoller S, Mueller S, Schild SE, Bandopadhayay P, Fouladi M, Bouffet E, Huang A, Onar-Thomas A, Gottardo NG

Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors.

Journal of neurosurgery

Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, McDermott MW, Raleigh DR, Braunstein SE

ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma.

Genome biology

Babikir H, Wang L, Shamardani K, Catalan F, Sudhir S, Aghi MK, Raleigh DR, Phillips JJ, Diaz AA

Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen.

ACS applied materials & interfaces

Meher N, Seo K, Wang S, Bidkar AP, Fogarty M, Dhrona S, Huang X, Tang R, Blaha C, Evans MJ, Raleigh DR, Jun YW, VanBrocklin HF, Desai TA, Wilson DM, Ozawa T, Flavell RR

Mouse models of glioblastoma for the evaluation of novel therapeutic strategies.

Neuro-oncology advances

Haddad AF, Young JS, Amara D, Berger MS, Raleigh DR, Aghi MK, Butowski NA

Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis.

JAMA oncology

Chen WC, Baal UH, Baal JD, Pai JS, Boreta L, Braunstein SE, Raleigh DR

Residents-as-Teachers Curriculum for Radiation Oncology: A Targeted Needs Assessment.

International journal of radiation oncology, biology, physics

Ni L, Thomas HR, Raleigh DR, Boreta LC, Park CC, Braunstein SE

Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy.

Neurosurgery

Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR

A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma.

Journal of neuro-oncology

Bush NAO, Young JS, Zhang Y, Dalle Ore CL, Molinaro AM, Taylor J, Clarke J, Prados M, Braunstein SE, Raleigh DR, Chang SM, Berger MS, Butowski NA

Sterol regulation of developmental and oncogenic Hedgehog signaling.

Biochemical pharmacology

Daggubati V, Raleigh DR, Sever N

Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.

The Journal of clinical investigation

Daggubati V, Hochstelter J, Bommireddy A, Choudhury A, Krup AL, Kaur P, Tong P, Li A, Xu L, Reiter JF, Raleigh DR

Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.

Neurosurgery

Vasudevan HN, Lucas CG, Villanueva-Meyer JE, Theodosopoulos PV, Raleigh DR

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.

The Journal of Cell Biology

Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR

A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.

Neurosurgery

Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW, Solomon DA, Theodosopoulos PV, Raleigh DR

Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival.

Neuro-oncology advances

Lucas CG, Vasudevan HN, Chen WC, Magill ST, Braunstein SE, Jacques L, Dahiya S, Rodriguez FJ, Horvai AE, Perry A, Pekmezci M, Raleigh DR

Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.

Nature communications

Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR

WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index.

Frontiers in oncology

Haddad AF, Young JS, Kanungo I, Sudhir S, Chen JS, Raleigh DR, Magill ST, McDermott MW, Aghi MK

The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.

Cancer discovery

Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.

Acta neuropathologica communications

Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR

DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma.

Acta neuropathologica communications

Vasudevan HN, Castro MRH, Lee JC, Villanueva-Meyer JE, Bush NAO, McDermott MW, Solomon DA, Perry A, Magill ST, Raleigh DR

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.

Genome biology

Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA

Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.

Cell reports

Liu SJ, Magill ST, Vasudevan HN, Hilz S, Villanueva-Meyer JE, Lastella S, Daggubati V, Spatz J, Choudhury A, Orr BA, Demaree B, Seo K, Ferris SP, Abate AR, Oberheim Bush NA, Bollen AW, McDermott MW, Costello JF, Raleigh DR

Clinical Implications of Primary Cilia in Skin Cancer.

Dermatology and therapy

Choudhury A, Neumann NM, Raleigh DR, Lang UE

Stereotactic Body Radiation Therapy of Adrenal Metastases: A Pooled Meta-Analysis and Systematic Review of 39 Studies with 1006 Patients.

International journal of radiation oncology, biology, physics

Chen WC, Baal JD, Baal U, Pai J, Gottschalk A, Boreta L, Braunstein SE, Raleigh DR

Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.

Cell stem cell

Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR

Preclinical models of meningioma: Cell culture and animal systems.

Handbook of clinical neurology

Choudhury A, Raleigh DR

Stereotactic Radiosurgery to More Than 10 Brain Metastases: Evidence to Support the Role of Radiosurgery for Ideal Hippocampal Sparing in the Treatment of Multiple Brain Metastases.

World neurosurgery

Susko MS, Garcia MA, Ma L, Nakamura JL, Raleigh DR, Fogh S, Theodosopoulos P, McDermott M, Sneed PK, Braunstein SE

Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.

Acta neuropathologica

Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA

Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.

Neuro-oncology advances

Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg TD, Braunstein SE, Sneed PK, Perry A, Zadeh G, McDermott MW, Villanueva-Meyer JE, Raleigh DR

Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.

Molecular pharmaceutics

Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR

Clinical, radiological, and histopathological predictors for long-term prognosis after surgery for atypical meningiomas.

Acta neurochirurgica

Streckert EMS, Hess K, Sporns PB, Adeli A, Brokinkel C, Kriz J, Holling M, Eich HT, Paulus W, Spille DC, van Eck ATCJ, Raleigh DR, McDermott MW, Stummer W, Brokinkel B

Reirradiation of recurrent high-grade glioma and development of prognostic scores for progression and survival.

Neuro-oncology practice

Chapman CH, Hara JH, Molinaro AM, Clarke JL, Oberheim Bush NA, Taylor JW, Butowski NA, Chang SM, Fogh SE, Sneed PK, Nakamura JL, Raleigh DR, Braunstein SE

Meningioma metastases: incidence and proposed screening paradigm.

Journal of neurosurgery

Dalle Ore CL, Magill ST, Yen AJ, Shahin MN, Lee DS, Lucas CG, Chen WC, Viner JA, Aghi MK, Theodosopoulos PV, Raleigh DR, Villanueva-Meyer JE, McDermott MW

Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma.

Cancer research

Voce DJ, Bernal GM, Wu L, Crawley CD, Zhang W, Mansour NM, Cahill KE, Szymura SJ, Uppal A, Raleigh DR, Spretz R, Nunez L, Larsen G, Khodarev NN, Weichselbaum RR, Yamini B

Preoperative Dural Contact and Recurrence Risk After Surgical Cavity Stereotactic Radiosurgery for Brain Metastases: New Evidence in Support of Consensus Guidelines.

Advances in radiation oncology

Susko M, Yu Y, Ma L, Nakamura J, Fogh S, Raleigh DR, Golden E, Theodosopoulos PV, McDermott MW, Sneed PK, Braunstein SE

Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma.

Acta neuropathologica

Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA

Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes.

AJNR. American journal of neuroradiology

Baal JD, Chen WC, Solomon DA, Pai JS, Lucas CH, Hara JH, Oberheim Bush NA, McDermott MW, Raleigh DR, Villanueva-Meyer JE

Misactivation of Hedgehog signaling causes inherited and sporadic cancers.

The Journal of clinical investigation

Raleigh DR, Reiter JF

Advances in multidisciplinary therapy for meningiomas.

Neuro-Oncology

Brastianos PK, Galanis E, Butowski N, Chan JW, Dunn IF, Goldbrunner R, Herold-Mende C, Ippen FM, Mawrin C, McDermott MW, Sloan A, Snyder J, Tabatabai G, Tatagiba M, Tonn JC, Wen PY, Aldape K, Nassiri F, Zadeh G, Jenkinson MD, Raleigh DR, International Consortium on Meningiomas

Erratum: "Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers" [Med. Phys. 45 (7), 3449-3459 (2018)].

Medical physics

Deist TM, Dankers FJWM, Valdes G, Wijsman R, Hsu IC, Oberije C, Lustberg T, van Soest J, Hoebers F, Jochems A, El Naqa I, Wee L, Morin O, Raleigh DR, Bots W, Kaanders JH, Belderbos J, Kwint M, Solberg T, Monshouwer R, Bussink J, Dekker A, Lambin P

The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.

Acta neuropathologica

Fritchie K, Jensch K, Moskalev EA, Caron A, Jenkins S, Link M, Brown PD, Rodriguez FJ, Guajardo A, Brat D, Velázquez Vega JE, Perry A, Wu A, Raleigh DR, Santagata S, Louis DN, Brastianos PK, Kaplan A, Alexander BM, Rossi S, Ferrarese F, Haller F, Giannini C

Surgical outcomes after reoperation for recurrent non-skull base meningiomas.

Journal of neurosurgery

Magill ST, Dalle Ore CL, Diaz MA, Jalili DD, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW

Cilia-Associated Oxysterols Activate Smoothened.

Molecular cell

Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF

Preoperative and postoperative prediction of long-term meningioma outcomes.

PloS one

Gennatas ED, Wu A, Braunstein SE, Morin O, Chen WC, Magill ST, Gopinath C, Villaneueva-Meyer JE, Perry A, McDermott MW, Solberg TD, Valdes G, Raleigh DR

Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers.

Medical physics

Deist TM, Dankers FJWM, Valdes G, Wijsman R, Hsu IC, Oberije C, Lustberg T, van Soest J, Hoebers F, Jochems A, El Naqa I, Wee L, Morin O, Raleigh DR, Bots W, Kaanders JH, Belderbos J, Kwint M, Solberg T, Monshouwer R, Bussink J, Dekker A, Lambin P

Clinical Applications of Quantitative 3-Dimensional MRI Analysis for Pediatric Embryonal Brain Tumors.

International journal of radiation oncology, biology, physics

Hara JH, Wu A, Villanueva-Meyer JE, Valdes G, Daggubati V, Mueller S, Solberg TD, Braunstein SE, Morin O, Raleigh DR

Surgical Outcomes, Complications, and Management Strategies for Foramen Magnum Meningiomas.

Journal of neurological surgery. Part B, Skull base

Magill ST, Shahin MN, Lucas CG, Yen AJ, Lee DS, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW

Surgical outcomes after reoperation for recurrent skull base meningiomas.

Journal of neurosurgery

Magill ST, Lee DS, Yen AJ, Lucas CG, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW

How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In.

Current biology : CB

Garcia G, Raleigh DR, Reiter JF

Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy.

Journal of neurosurgery

Chen WC, Magill ST, Wu A, Vasudevan HN, Morin O, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Braunstein SE, Raleigh DR

Petrous Face Meningiomas: Classification, Clinical Syndromes, and Surgical Outcomes.

World neurosurgery

Magill ST, Rick JW, Chen WC, Haase DA, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW

Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation.

Cell reports

Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR

Salvage therapy outcomes for atypical meningioma.

Journal of neuro-oncology

Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE

Presenting Symptoms and Prognostic Factors for Symptomatic Outcomes Following Resection of Meningioma.

World neurosurgery

Wu A, Garcia MA, Magill ST, Chen W, Vasudevan HN, Perry A, Theodosopoulos PV, McDermott MW, Braunstein SE, Raleigh DR

Hedgehog signaling drives medulloblastoma growth via CDK6.

The Journal of clinical investigation

Raleigh DR, Choksi PK, Krup AL, Mayer W, Santos N, Reiter JF

Case-based review: pediatric medulloblastoma.

Neuro-oncology practice

Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S

Management of Chordoma and Chondrosarcoma with Fractionated Stereotactic Radiotherapy.

Frontiers in surgery

Vasudevan HN, Raleigh DR, Johnson J, Garsa AA, Theodosopoulos PV, Aghi MK, Ames C, McDermott MW, Barani IJ, Braunstein SE

Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.

Neuro-Oncology

Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA

Pediatric high-grade glioma: current molecular landscape and therapeutic approaches.

Journal of neuro-oncology

Braunstein S, Raleigh D, Bindra R, Mueller S, Haas-Kogan D

Surgical Resection and Interstitial Iodine-125 Brachytherapy for High-Grade Meningiomas: A 25-Year Series.

Neurosurgery

Magill ST, Lau D, Raleigh DR, Sneed PK, Fogh SE, McDermott MW

Survival after chemotherapy and stem cell transplant followed by delayed craniospinal irradiation is comparable to upfront craniospinal irradiation in pediatric embryonal brain tumor patients.

Journal of neuro-oncology

Raleigh DR, Tomlin B, Buono BD, Roddy E, Sear K, Byer L, Felton E, Banerjee A, Torkildson J, Samuel D, Horn B, Braunstein SE, Haas-Kogan DA, Mueller S

Educational Impact of a Structured Radiation Oncology Clerkship Curriculum: An Interinstitutional Comparison.

Journal of the American College of Radiology : JACR

Oskvarek JJ, Brower JV, Mohindra P, Raleigh DR, Chmura SJ, Golden DW

Discovery of additional brain metastases on the day of stereotactic radiosurgery: risk factors and outcomes.

Journal of neurosurgery

Garcia MA, Lazar A, Duriseti S, Raleigh DR, Hess CP, Fogh SE, Barani IJ, Nakamura JL, Larson DA, Theodosopoulos P, McDermott M, Sneed PK, Braunstein S

Resection and brain brachytherapy with permanent iodine-125 sources for brain metastasis.

Journal of neurosurgery

Raleigh DR, Seymour ZA, Tomlin B, Theodosopoulos PV, Berger MS, Aghi MK, Geneser SE, Krishnamurthy D, Fogh SE, Sneed PK, McDermott MW

Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.

Neuro-Oncology

Raleigh DR, Solomon DA, Lloyd SA, Lazar A, Garcia MA, Sneed PK, Clarke JL, McDermott MW, Berger MS, Tihan T, Haas-Kogan DA

Parameters influencing local control of meningiomas treated with radiosurgery.

Journal of neuro-oncology

Kaprealian T, Raleigh DR, Sneed PK, Nabavizadeh N, Nakamura JL, McDermott MW

Meningiomas With Rhabdoid Features Lacking Other Histologic Features of Malignancy: A Study of 44 Cases and Review of the Literature.

Journal of neuropathology and experimental neurology

Vaubel RA, Chen SG, Raleigh DR, Link MJ, Chicoine MR, Barani I, Jenkins SM, Aleff PA, Rodriguez FJ, Burger PC, Dahiya S, Perry A, Giannini C

Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.

Acta neuropathologica

Menke JR, Raleigh DR, Gown AM, Thomas S, Perry A, Tihan T

Patient- and treatment-specific predictors of genitourinary function after high-dose-rate monotherapy for favorable prostate cancer.

Brachytherapy

Raleigh DR, Chang AJ, Tomlin B, Cunha JA, Braunstein SE, Shinohara K, Gottschalk AR, Roach M, Hsu IC

Induction Hedgehog pathway inhibition followed by combined-modality radiotherapy for basal cell carcinoma.

The British journal of dermatology

Raleigh DR, Algazi A, Arron ST, Neuhaus IM, Yom SS

S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability.

Cell cycle (Georgetown, Tex.)

Crawley CD, Kang S, Bernal GM, Wahlstrom JS, Voce DJ, Cahill KE, Garofalo A, Raleigh DR, Weichselbaum RR, Yamini B

The management of central neurocytoma: radiotherapy.

Neurosurgery clinics of North America

Barani IJ, Raleigh DR, Larson D

Bladder wall recurrence of prostate cancer after high-dose-rate brachytherapy.

Brachytherapy

Raleigh DR, Hsu IC, Braunstein S, Chang AJ, Simko JP, Roach M

A national radiation oncology medical student clerkship survey: didactic curricular components increase confidence in clinical competency.

International journal of radiation oncology, biology, physics

Jagadeesan VS, Raleigh DR, Koshy M, Howard AR, Chmura SJ, Golden DW

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux.

Molecular biology of the cell

Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR

Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.

Future oncology (London, England)

Raleigh DR, Haas-Kogan DA

DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site.

Nucleic Acids Research

Crawley CD, Raleigh DR, Kang S, Voce DJ, Schmitt AM, Weichselbaum RR, Yamini B

A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.

Development (Cambridge, England)

Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC

Radiation oncology fourth-year medical student clerkships: a targeted needs assessment.

International journal of radiation oncology, biology, physics

Golden DW, Raleigh DR, Chmura SJ, Koshy M, Howard AR

p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage.

Molecular cell

Schmitt AM, Crawley CD, Kang S, Raleigh DR, Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.

The Journal of Cell Biology

Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR

Tight junction pore and leak pathways: a dynamic duo.

Annual review of physiology

Shen L, Weber CR, Raleigh DR, Yu D, Turner JR

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.

Proceedings of the National Academy of Sciences of the United States of America

Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR

Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.

The Journal of Cell Biology

Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR

Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity.

The Journal of biological chemistry

Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR

Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.

Molecular biology of the cell

Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR

Faculty Type: 
Affiliate Faculty