Harold Chapman, MD

A fibroblast-dependent TGFß1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.

The Journal of clinical investigation

Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Jourdan Le Saux C

BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA

A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis.

bioRxiv : the preprint server for biology

Cohen ML, Brumwell AN, Che Ho T, Montas G, Golden JA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ

Human distal airways contain a multipotent secretory cell that can regenerate alveoli.

Nature

Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.

Nature cell biology

Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T

Nuclear IL-33 as a growth and survival agent within basal cells.

The Journal of clinical investigation

Chapman HA

Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity.

Cell reports

Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, Guo HF, Yu J, Rodriguez BL, Firestone JJA, Mino B, Creighton CJ, Solis LM, Villalobos P, Raso MG, Sazer DW, Gibbons DL, Russell WK, Longmore GD, Wistuba II, Wang J, Chapman HA, Miller JS, Zong C, Kurie JM

Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.

Thorax

Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion.

Nature communications

Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.

Nature communications

Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB

Reversal of TGFβ1-Driven Profibrotic State in Patients with Pulmonary Fibrosis.

The New England journal of medicine

Chapman HA, Wei Y, Montas G, Leong D, Golden JA, Trinh BN, Wolters PJ, Le Saux CJ, Jones KD, Hills NK, Foster E, Oldham JM, Linderholm AL, Kotak P, Decaris M, Turner S, Song JW

VEGF Drives the Car toward Better Gas Exchange.

Developmental cell

Kathiriya JJ, Chapman HA

Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration.

Cell stem cell

Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA

Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.

JCI insight

Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C

B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes.

Frontiers in immunology

Egia-Mendikute L, Arpa B, Rosell-Mases E, Corral-Pujol M, Carrascal J, Carrillo J, Mora C, Chapman H, Panosa A, Vives-Pi M, Stratmann T, Serreze D, Verdaguer J

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.

The Journal of clinical investigation

LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.

PloS one

Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR

Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited.

American journal of respiratory cell and molecular biology

Le Saux CJ, Chapman HA

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.

The Journal of clinical investigation

Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T

TGF-β1 Signaling and Tissue Fibrosis.

Cold Spring Harbor perspectives in biology

Kim KK, Sheppard D, Chapman HA

Extracellular matrix in lung development, homeostasis and disease.

Matrix biology : journal of the International Society for Matrix Biology

Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ

Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.

The Journal of clinical investigation

Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.

Nature cell biology

Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE

Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.

The American journal of pathology

McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL

Failure of Alveolar Type 2 Cell Maintenance Links Neonatal Distress with Adult Lung Disease.

American journal of respiratory cell and molecular biology

Vaughan AE, Chapman HA

Persistent Pathology in Influenza-Infected Mouse Lungs.

American journal of respiratory cell and molecular biology

Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.

Nature

Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA

Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.

Molecular cell

Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R

Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

Cell stem cell

Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE

Soluble urokinase-type plasminogen activator receptor in FSGS: stirred but not shaken.

Journal of the American Society of Nephrology : JASN

Reiser J, Chapman H

Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts.

The Journal of biological chemistry

Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

American journal of respiratory and critical care medicine

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP

Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline.

American journal of respiratory cell and molecular biology

Xi Y, Tan K, Brumwell AN, Chen SC, Kim YH, Kim TJ, Wei Y, Chapman HA

BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.

Science translational medicine

Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS

Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins.

The American journal of pathology

Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK

Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.

American journal of respiratory and critical care medicine

Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ

Molecular determinants of lung development.

Annals of the American Thoracic Society

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS

Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.

Human molecular genetics

Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M

Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.

Oncogene

Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA

Regenerative activity of the lung after epithelial injury.

Biochimica et biophysica acta

Vaughan AE, Chapman HA

Epithelial responses to lung injury: role of the extracellular matrix.

Proceedings of the American Thoracic Society

Chapman HA

Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors.

Cancer discovery

Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM

Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis.

The Journal of biological chemistry

Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice.

The Journal of clinical investigation

Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH

Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.

Proceedings of the American Thoracic Society

Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D

Toward lung regeneration.

The New England journal of medicine

Chapman HA

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ

Epithelial-mesenchymal interactions in pulmonary fibrosis.

Annual review of physiology

Chapman HA

Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins.

American journal of physiology. Lung cellular and molecular physiology

Zhu S, Gladson CL, White KE, Ding Q, Stewart J, Jin TH, Chapman HA, Olman MA

Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis.

Development (Cambridge, England)

Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA

Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts.

The Journal of Cell Biology

Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA

Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.

The Journal of clinical investigation

Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA

Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins.

Journal of cell science

Tang CH, Hill ML, Brumwell AN, Chapman HA, Wei Y

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

Nature

Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM

Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis.

American journal of respiratory cell and molecular biology

Kim KK, Chapman HA

Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells.

The Journal of biological chemistry

Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA

Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.

Journal of immunology (Baltimore, Md. : 1950)

Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.

Proceedings of the National Academy of Sciences of the United States of America

Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA

Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice.

Biological chemistry

Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ

The SERPINE2 gene is associated with chronic obstructive pulmonary disease.

Proceedings of the American Thoracic Society

DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK

Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.

The Journal of biological chemistry

Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS

Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease.

Molecular and Cellular Biology

Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA

Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors.

The Journal of biological chemistry

Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP

The SERPINE2 gene is associated with chronic obstructive pulmonary disease.

American journal of human genetics

Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK

Endosomal proteases in antigen presentation.

Current opinion in immunology

Chapman HA

Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.

Immunology

Kala M, Chen CR, McLachlan SM, Rapoport B, Aliesky H, Chapman HA

A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease.

American journal of respiratory cell and molecular biology

Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA

Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.

Journal of immunology (Baltimore, Md. : 1950)

Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA

Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis.

Journal of immunology (Baltimore, Md. : 1950)

Yang H, Kala M, Scott BG, Goluszko E, Chapman HA, Christadoss P

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

The Journal of Cell Biology

Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA

Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.

Circulation research

Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP

Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions.

Arteriosclerosis, thrombosis, and vascular biology

Aslanian AM, Chapman HA, Charo IF

Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine

DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST, Silverman EK

Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice.

Circulation

Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).

Human molecular genetics

Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK

Cathepsins as transcriptional activators?

Developmental cell

Chapman HA

Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD.

Thorax

DeMeo DL, Carey VJ, Chapman HA, Reilly JJ, Ginns LC, Speizer FE, Weiss ST, Silverman EK

Proteases, extracellular matrix, and cancer: a workshop of the path B study section.

The American journal of pathology

DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M

Disorders of lung matrix remodeling.

The Journal of clinical investigation

Chapman HA

Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact.

The Journal of Cell Biology

Zhang F, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, Chapman HA

Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5.

Biological chemistry

Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G

Matrilysin-dependent elastolysis by human macrophages.

The Journal of experimental medicine

Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ

Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease.

Human molecular genetics

Palmer LJ, Celedón JC, Chapman HA, Speizer FE, Weiss ST, Silverman EK

Deficiency of the cysteine protease cathepsin S impairs microvessel growth.

Circulation research

Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P

Urokinase receptor and integrin interactions.

Current pharmaceutical design

Kugler MC, Wei Y, Chapman HA

The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease.

Journal of immunology (Baltimore, Md. : 1950)

Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS

Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.

American journal of respiratory and critical care medicine

Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA

The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen.

Journal of immunology (Baltimore, Md. : 1950)

Wu ZQ, Shen Y, Khan AQ, Chu CL, Riese R, Chapman HA, Kanagawa O, Snapper CM

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.

Molecular and biochemical parasitology

Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH

Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease.

American journal of human genetics

Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST

Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes.

Human molecular genetics

Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST

Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts.

Chest

Zhu S, Gladson CL, Stewart J, White KE, Chapman HA, Olman MA

Random peptide bacteriophage display as a probe for urokinase receptor ligands.

Biological chemistry

Fong S, Doyle MV, Goodson RJ, Drummond RJ, Stratton JR, McGuire L, Doyle LV, Chapman HA, Rosenberg S

Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.

Immunity

Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA

Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

Molecular biology of the cell

Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA

Protease crosstalk with integrins: the urokinase receptor paradigm.

Thrombosis and haemostasis

Chapman HA, Wei Y

Expression of cathepsins B and S in the progression of prostate carcinoma.

International journal of cancer

Fernández PL, Farré X, Nadal A, Fernández E, Peiró N, Sloane BF, Shi GP, Chapman HA, Campo E, Cardesa A

Interferon gamma induction of pulmonary emphysema in the adult murine lung.

The Journal of experimental medicine

Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA

Gender-related differences in severe, early-onset chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine

Silverman EK, Weiss ST, Drazen JM, Chapman HA, Carey V, Campbell EJ, Denish P, Silverman RA, Celedon JC, Reilly JJ, Ginns LC, Speizer FE

Importance of lysosomal cysteine proteases in lung disease.

Respiratory research

Wolters PJ, Chapman HA

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.

The Journal of clinical investigation

Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA

Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.

Biochemistry

Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA

Protease injury in the development of COPD: Thomas A. Neff Lecture.

Chest

Chapman HA, Shi GP

Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function.

The Journal of biological chemistry

Simon DI, Wei Y, Zhang L, Rao NK, Xu H, Chen Z, Liu Q, Rosenberg S, Chapman HA

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.

The Journal of experimental medicine

Shi GP, Bryant RA, Riese R, Verhelst S, Driessen C, Li Z, Bromme D, Ploegh HL, Chapman HA

Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.

The EMBO journal

Villadangos JA, Driessen C, Shi GP, Chapman HA, Ploegh HL

Nonproteolytic role for the urokinase receptor in cellular migration in vivo.

American journal of respiratory cell and molecular biology

Waltz DA, Fujita RM, Yang X, Natkin L, Zhuo S, Gerard CJ, Rosenberg S, Chapman HA

Cathepsins and compartmentalization in antigen presentation.

Current opinion in immunology

Riese RJ, Chapman HA

Proteases involved in MHC class II antigen presentation.

Immunological reviews

Villadangos JA, Bryant RA, Deussing J, Driessen C, Lennon-Duménil AM, Riese RJ, Roth W, Saftig P, Shi GP, Chapman HA, Peters C, Ploegh HL

Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.

The Journal of Cell Biology

Driessen C, Bryant RA, Lennon-Duménil AM, Villadangos JA, Bryant PW, Shi GP, Chapman HA, Ploegh HL

Cystatin C deficiency in human atherosclerosis and aortic aneurysms.

The Journal of clinical investigation

Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA

Role of urokinase receptor and caveolin in regulation of integrin signaling.

Thrombosis and haemostasis

Chapman HA, Wei Y, Simon DI, Waltz DA

A Fas pathway to pulmonary fibrosis.

The Journal of clinical investigation

Chapman HA

A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling.

The Journal of Cell Biology

Wei Y, Yang X, Liu Q, Wilkins JA, Chapman HA

Cathepsin S required for normal MHC class II peptide loading and germinal center development.

Immunity

Shi GP, Villadangos JA, Dranoff G, Small C, Gu L, Haley KJ, Riese R, Ploegh HL, Chapman HA

Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.

The Journal of biological chemistry

Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Brömme D

Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation.

Journal of immunology (Baltimore, Md. : 1950)

Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.

The Journal of clinical investigation

Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P

Cathepsin S activity regulates antigen presentation and immunity.

The Journal of clinical investigation

Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA

Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis.

American journal of respiratory and critical care medicine

Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE

Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.

Biochemistry

Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Brömme D, Chapman HA, Silverman GA

Endosomal proteolysis and MHC class II function.

Current opinion in immunology

Chapman HA

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.

The Journal of pharmacology and experimental therapeutics

Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA