Michael Grabe, PhD

Grabe
Professor
Cardiovascular Research Institute
+1 415 502-2874
Education and Training
07/2021
University of California, San Francisco
Diversity, Equity, and Inclusion Champion Training
07/2021
University of California, San Francisco
Diversity, Equity, and Inclusion Champion Training
Research Activities And Funding
Jan 1, 2021 - Nov 30, 2024

Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins

NIH R01GM137109

Role: Principal Investigator
Sep 1, 2012 - Jul 31, 2015

Computer simulations of lysosomal and osteoclast microphysiology

NIH R21GM100224

Role: Principal Investigator
ORCID
0000-0003-3509-5997 Additional info
Faculty Type
Core CVRI Faculty

Research Summary:
Our lab uses computational methods to understand biological phenomena. We are primarily interested in the mechanical operation of ion channels and transporters, which move ions and small molecules across membranes. Additionally, we use theoretical approaches to explore how these membrane proteins work together to regulate ion homeostasis in organelles such as the lysosome and Golgi. Lastly, we are developing methodologies for predicting the stability of membrane proteins to understand how mutations give rise to a loss of function, improper trafficking or degradation.

Publications

Cilia-Associated Oxysterols Activate Smoothened.

Molecular cell

Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF

Address

555 & 535 Mission Bay Blvd Sou, Rm 452T
UCSF Box 3122
San Francisco, CA 94158
United States