Pao-Tien Chuang, MD, PhD

Professor

Cardiovascular Research Institute

Research Interests

Signaling pathways in lung development and repair

[email protected]

+1 415 514-0667

Faculty Type

Core CVRI Faculty

Research Summary:

Cell-cell signaling during mammalian development and in postnatal physiology Summary: We use mouse as a model system to understand how embryos develop. This knowledge is critical for understanding the basis of human congenital defects. Moreover, many adult diseases have their origin in development. Thus, our studies have important implications for developing stem cell therapy and identifying the cause of cancers.

Publications

The alveolus: Our current knowledge of how the gas exchange unit of the lung is constructed and repaired.

Current topics in developmental biology

Zhang K, Yao E, Aung T, Chuang PT

Lung patterning: Is a distal-to-proximal gradient of cell allocation and fate decision a general paradigm?: A gradient of distal-to-proximal distribution and differentiation of tip progenitors produces distinct compartments in the lung.

BioEssays : news and reviews in molecular, cellular and developmental biology

Zhang K, Aung T, Yao E, Chuang PT

Monitoring the performance of a dedicated weaning unit using risk-adjusted control charts for the weaning rate in prolonged mechanical ventilation.

Journal of the Formosan Medical Association = Taiwan yi zhi

Huang HF, Jerng JS, Hsu PJ, Lin NH, Lin LM, Hung SM, Kuo YW, Ku SC, Chuang PY, Chen SY

mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity.

Nature communications

Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Chuang PT

Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions.

PLoS biology

Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT

A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.

Developmental cell

Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT

Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.

eLife

Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT

A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis.

eLife

Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT

Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury.

Stem cells (Dayton, Ohio)

Yao E, Lin C, Wu Q, Zhang K, Song H, Chuang PT

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis.

eLife

Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT

Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma.

The Journal of biological chemistry

Song H, Lin C, Yao E, Zhang K, Li X, Wu Q, Chuang PT

A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.

Developmental biology

Lin C, Yao E, Chuang PT

Hedgehog signaling: From basic research to clinical applications.

Journal of the Formosan Medical Association = Taiwan yi zhi

Yao E, Chuang PT

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.

Genes & development

Lin C, Yao E, Wang K, Nozawa Y, Shimizu H, Johnson JR, Chen JN, Krogan NJ, Chuang PT

Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.

Developmental biology

Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT

A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.

Developmental cell

Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC

Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis.

Developmental biology

Nozawa YI, Yao E, Gacayan R, Xu SM, Chuang PT

Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.

Developmental dynamics : an official publication of the American Association of Anatomists

Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang PT

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction.

Current opinion in genetics & development

Nozawa YI, Lin C, Chuang PT

Alveolar type II cells possess the capability of initiating lung tumor development.

PloS one

Lin C, Song H, Huang C, Yao E, Gacayan R, Xu SM, Chuang PT

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America

Song H, Yao E, Lin C, Gacayan R, Chen MH, Chuang PT

The path to chemotaxis and transcription is smoothened.

Science signaling

Lin C, Nozawa YI, Chuang PT

A cell-based screen for inhibitors of flagella-driven motility in Chlamydomonas reveals a novel modulator of ciliary length and retrograde actin flow.

Cytoskeleton (Hoboken, N.J.)

Engel BD, Ishikawa H, Feldman JL, Wilson CW, Chuang PT, Snedecor J, Williams J, Sun Z, Marshall WF

Mechanism and evolution of cytosolic Hedgehog signal transduction.

Development (Cambridge, England)

Wilson CW, Chuang PT

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

Genes & development

Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

PloS one

Wilson CW, Chen MH, Chuang PT

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Nature

Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

Developmental cell

Mak KK, Bi Y, Wan C, Chuang PT, Clemens T, Young M, Yang Y

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.

Development (Cambridge, England)

Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.

Nature cell biology

Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF

SnapShot: hedgehog signaling pathway.

Cell

Chen MH, Wilson CW, Chuang PT

The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation.

Oncogene

Gerber AN, Wilson CW, Li YJ, Chuang PT

Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.

Development (Cambridge, England)

Mak KK, Chen MH, Day TF, Chuang PT, Yang Y

Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.

Developmental biology

Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M

New "hogs" in Hedgehog transport and signal reception.

Cell

Wilson CW, Chuang PT

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.

Development (Cambridge, England)

Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND

Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development.

Molecular and Cellular Biology

Chen MH, Gao N, Kawakami T, Chuang PT

N-myristoyltransferase 1 is essential in early mouse development.

The Journal of biological chemistry

Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG, Peters LL, Chuang PT, Young SG, Bergo MO

Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein.

The Journal of experimental medicine

Vogt A, Chuang PT, Hebert J, Hwang J, Lu Y, Kopelovich L, Athar M, Bickers DR, Epstein EH

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.

Genes & development

Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT

Continuous lateral rotational therapy in the medical intensive care unit.

Journal of the Formosan Medical Association = Taiwan yi zhi

Wang JY, Chuang PY, Lin CJ, Yu CJ, Yang PC

Combined activities of hedgehog signaling inhibitors regulate pancreas development.

Development (Cambridge, England)

Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M

Branching morphogenesis of the lung: new molecular insights into an old problem.

Trends in cell biology

Chuang PT, McMahon AP

Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung.

Genes & development

Chuang PT, Kawcak T, McMahon AP

Determination of the chromosomal location and genomic structure of the Hedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly.

International Journal of Genomics

Liang Huo, Erich Roessler, Amalia Dutra, Pao-Tien Chuang, A. P. McMahon, Maximilian Muenke

Determination of the chromosomal location and genomic structure of theHedgehog-Interacting Protein gene, and analysis of its role in Holoprosencephaly.

International Journal of Genomics

Liang Huo, Erich Roessler, Amalia Dutra, Pao-Tien Chuang, A. P. McMahon, Maximilian Muenke

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.

Development (Cambridge, England)

Yang Y, Drossopoulou G, Chuang PT, Duprez D, Marti E, Bumcrot D, Vargesson N, Clarke J, Niswander L, McMahon A, Tickle C

Hedgehogs in the clinic.

Nature medicine

McMahon AP, Chuang PT

DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation.

Development (Cambridge, England)

Hsu DR, Chuang PT, Meyer BJ

DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome.

Cell

Chuang PT, Albertson DG, Meyer BJ

https://profiles.ucsf.edu/pao-tien.chuang

Address

555 & 535 Mission Bay Blvd Sou, Rm 252F
UCSF Box 3118
San Francisco, CA 94158
United States