Phillip Dumesic, MD, PhD

Assistant Professor, Diabetes Center
Dumesic
UCSF Profiles(link is external)
Address: 
513 Parnassus Avenue, HSW, Rm 1118
San Francisco, CA 94143
United States
Email: 
phillip.dumesic@ucsf.edu
Faculty Type: 
Affiliate Faculty

We study how genes determine cellular decisions in energy metabolism, how organisms coordinate such decisions to maintain energy balance, and how new therapies might modulate these processes to treat diseases such as obesity, diabetes, sarcopenia, and cachexia. We apply genetics, biochemistry, and physiology—all driven by individual curiosity and diverse ways of thought.

Publications: 

RBM43 controls PGC1α translation and a PGC1α-STING signaling axis.(link is external)

Cell metabolism

Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM

p38α kinase governs muscle strength through PGC1α in mice.(link is external)

Acta physiologica (Oxford, England)

Herrera-Melle L, Cicuéndez B, López JA, Dumesic PA, Wilensky SE, Rodríguez E, Leiva-Vega L, Caballero A, León M, Vázquez J, Spiegelman BM, Folgueira C, Mora A, Sabio G

Remodeling p38 signaling in muscle controls locomotor activity via IL-15.(link is external)

Science advances

Folgueira C, Herrera-Melle L, López JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, García-Culebras A, Dumesic PA, Rodríguez E, Leiva-Vega L, León M, Porteiro B, Iglesias C, Torres JL, Hernández-Cosido L, Bonacasa C, Marcos M, Moro MÁ, Vázquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G

Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.(link is external)

Cell metabolism

Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer SM, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma AK, Balaz M, Wolfrum C, Spiegelman BM

REPTOR and CREBRF encode key regulators of muscle energy metabolism.(link is external)

Nature communications

Saavedra P, Dumesic PA, Hu Y, Filine E, Jouandin P, Binari R, Wilensky SE, Rodiger J, Wang H, Chen W, Liu Y, Spiegelman BM, Perrimon N

Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.(link is external)

Cell metabolism

Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1a.(link is external)

bioRxiv : the preprint server for biology

Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM

SnapShot: Regulation and biology of PGC-1a.(link is external)

Cell

Jannig PR, Dumesic PA, Spiegelman BM, Ruas JL

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.(link is external)

Nature

Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM

Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellu(link is external)

Clinical epigenetics

Leung KL, Sanchita S, Pham CT, Davis BA, Okhovat M, Ding X, Dumesic P, Grogan TR, Williams KJ, Morselli M, Ma F, Carbone L, Li X, Pellegrini M, Dumesic DA, Chazenbalk GD

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