Wendell Lim, PhD

Professor, Cellular Molecular Pharmacology

Research Interests: Signal transduction, synthetic biology, systems biology, structural biology, protein-protein interactions, cell motility, MAP kinase cascades, GTPase pathways Summary: Wendell Lim's Lab is working on creating a detailed instruction manual - a sort of user's guide - that explains how biochemical circuits control a cell's function and ultimately its fate. The long-term goal is to use the instruction manual to help scientists design cells to deliver therapeutic payloads, repair cancerous lesions, or attack microscopic pathogens. Cells are complex mechanical and sensing devices that can carry out highly complex tasks, such as secreting antibodies or forming repair structures like blood clots and bone. Cells contain signaling pathways that take in and integrate vast amounts of information about the cells' environment, and they process and use this information to make complex decisions about how to respond to changing environmental conditions. If more is understood about how these processes work, there is the potential to change cells and help solve problems in biotechnology or health, and to treat disease more rationally.

Address: 
600 16th Street, Rm N412E
UCSF Box 2280
San Francisco, CA 94158
United States
Phone: 
+1 415 502-8080
Faculty Type: 
Affiliate Faculty
Publications: 

Engineered SH3-Derived Sherpabodies Function as a Modular Platform for Targeted T-cell Immunotherapy.(link is external)

Cancer research

Hernández-López RA, Kesti T, Mäkelä AR, Zhao Z, Yu W, Tonai Y, Monzo HJ, Kalander K, Leppä S, Ojala PM, Lim WA, Saksela K

Synthetic organizer cells guide development via spatial and biochemical instructions.(link is external)

Cell

Yamada T, Trentesaux C, Brunger JM, Xiao Y, Stevens AJ, Martyn I, Kasparek P, Shroff NP, Aguilar A, Bruneau BG, Boffelli D, Klein OD, Lim WA

Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.(link is external)

Science (New York, N.Y.)

Reddy NR, Maachi H, Xiao Y, Simic MS, Yu W, Tonai Y, Cabanillas DA, Serrano-Wu E, Pauerstein PT, Tamaki W, Allen GM, Parent AV, Hebrok M, Lim WA

Programming tissue-sensing T cells that deliver therapies to the brain.(link is external)

Science (New York, N.Y.)

Simic MS, Watchmaker PB, Gupta S, Wang Y, Sagan SA, Duecker J, Shepherd C, Diebold D, Pineo-Cavanaugh P, Haegelin J, Zhu R, Ng B, Yu W, Tonai Y, Cardarelli L, Reddy NR, Sidhu SS, Troyanskaya O, Hauser SL, Wilson MR, Zamvil SS, Okada H, Lim WA

De novo-designed minibinders expand the synthetic biology sensing repertoire.(link is external)

bioRxiv : the preprint server for biology

Weinberg ZY, Soliman SS, Kim MS, Shah DH, Chen IP, Ott M, Lim WA, El-Samad H

Degron-Based bioPROTACs for Controlling Signaling in CAR T Cells.(link is external)

ACS synthetic biology

Kim MS, Bhargava HK, Shavey GE, Lim WA, El-Samad H, Ng AH

DIPG-15. NOVEL CNS SENSING SYNNOTCH-CAR T CELLS FOR TARGETING DIFFUSE MIDLINE GLIOMA.

Neuro-Oncology

Senthilnath Lakshmanachetty, Milos Simic, Jeffrey Haegelin, Payal Watchmaker, Haoyu Long, Jason Deucker, Robert Zhu, Chanelle Sheperd, Wei Yu, Ben Ng, Yuan Wang, Olga Troyanskaya, Lia Cardarelli, Sachdev Sidhu, Wendell Lim, Hideho Okada

Degron-based bioPROTACs for controlling signaling in CAR T cells.(link is external)

bioRxiv : the preprint server for biology

Kim MS, Bhargava HK, Shavey GE, Lim WA, El-Samad H, Ng AH

The General Characteristics and Design Taxonomy of Chatbots for COVID-19: A Systematic Review.(link is external)

Journal of medical Internet research

Lim WA, Custodio R, Sunga M, Amoranto AJ, Sarmiento RF

Golden age of immunoengineering.(link is external)

Immunological reviews

Wong WW, Lim WA

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