
Zian H. Tseng, M.D., M.A.S., a cardiologist and a cardiac electrophysiologist, has special interest in risk stratification of patients prone to sudden death and ventricular arrhythmias. He was born and raised in the Bay Area and is an alumnus of the UCSF School of Medicine, where he also completed a year of graduate studies in Biomedical Sciences and a Masters in Clinical Research. He completed his clinical training in internal medicine, cardiology, and cardiac electrophysiology at UCSF.
CLINICAL INTERESTS:
1) Treatment of complex supraventricular arrhythmias, including catheter ablation of atrial fibrillation and left atrial tachycardias occurring after atrial fibrillation ablation
2) Treatment and catheter ablation of ventricular tachycardia, including epicardial mapping and ablation
3) Treatment, risk stratification, and catheter ablation of arrhythmias in adult patients with congenital heart disease
4) Risk stratification and treatment of patients with genetic arrhythmia syndromes
5) Implantation of intracardiac devices for treatment of heart failure (resynchronization) and risk of sudden cardiac death (defibrillators)
6) Application of new device technologies
RESEARCH ACTIVITIES:
1) Principal Investigator for the POstmortem Systematic InvesTigation of Sudden Cardiac Death (POST SCD) Study, a collaboration with Dr. Ellen Moffatt in the San Francisco Office of the Chief Medical Examiner to more accurately define SCD, arrhythmic death, and its epidemiology, mechanisms, and risk factors, continuously funded by the NIH/NHLBI since 2010
2) Principal Investigator for the San Francisco POstmortem Systematic InvesTigation of Sudden Death Young (POST SDY) Study, to more accurately define sudden death in pediatric populations, funded by the CDC since 2015
3) Genetic epidemiology, novel molecular mechanisms, and risk factors for sudden cardiac arrest
4) Principal Investigator for NIH/NHLBI-funded HIV POST SCD Study: SCD and ventricular arrhythmias in the setting of HIV disease
5) Sudden neurologic death
6) Sudden death risk and public/health policy for use of Tasers (electrical conductive devices) by law enforcement agencies
Publications
Fragmented QRS, Arrhythmic Causes, and Myocardial Fibrosis Burden by Autopsy Among Countywide Sudden Deaths.
Countywide burden, pathology, and genetics of lethal hypertrophic cardiomyopathy: from the POST SCD study.
Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study.
Underlying Cause of Out-of-Hospital Cardiac Arrests in Japan in Survivors Versus Nonsurvivors.
Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study.
Heritable Burden of Community Sudden Death by Autopsy and Molecular Phenotyping for Precision Genotype Correlation.
TTN Variants, Dilated Cardiomyopathy, and Arrhythmic Causes by Autopsy Among Countywide Sudden Deaths.
HIV-Associated Heart Failure: Phenotypes and Clinical Outcomes in a Safety-Net Setting.
Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias.
Aberrancy masquerading as ventricular tachycardia: Importance of invasive electrophysiology study for diagnosis of wide complex tachycardias.
HIV-Associated Heart Failure: Phenotypes and Clinical Outcomes in a Safety-Net Setting.
Mechanical Dispersion Discriminates Between Arrhythmic and Nonarrhythmic Sudden Death: From the POST SCD Study.
Acute alcohol exposure and electrocardiographic changes: Finding from the HOLIDAY trial.
Homelessness and Incidence and Causes of Sudden Death: Data From the POST SCD Study.
The Lancet Commission to reduce the global burden of sudden cardiac death: a call for multidisciplinary action.
Exercises in Clinical Reasoning: Beyond the Surface.
Mechanical Dispersion Discriminates between Arrhythmic and Non-Arrhythmic Sudden Death: From the POST SCD Study.
A Randomized Trial of High vs Standard Power Radiofrequency Ablation for Pulmonary Vein Isolation: SHORT-AF.
Premature Atrial Contraction Location and Atrial Fibrillation Inducibility.
Heart Failure Burden by Autopsy, Guideline-Directed Medical Therapy, and ICD Utilization Among Sudden Deaths.
Randomized Comparison of a Radiofrequency Wire Versus a Radiofrequency Needle System for Transseptal Puncture.
The Value of Programmed Ventricular Extrastimuli From the Right Ventricular Basal Septum During Supraventricular Tachycardia.
Clinical Correlates and Outcomes of Methamphetamine-Associated Cardiovascular Diseases in Hospitalized Patients in California.
Human Immunodeficiency Virus Infection and Out-of-Hospital Cardiac Arrest.
Sudden Cardiac Death and Myocardial Fibrosis in Persons with HIV. Reply.
HIV Infection and the Risk of World Health Organization-Defined Sudden Cardiac Death.
Reply: Sudden Death: Thinking Beyond the Heart.
Human RyR2 (Ryanodine Receptor 2) Loss-of-Function Mutations: Clinical Phenotypes and In Vitro Characterization.
Acute Consumption of Alcohol and Discrete Atrial Fibrillation Events.
Fishing for an Association With Sudden Cardiac Death.
Atrial Tachycardia Ablation at the Pulmonic Valve in a Patient With Congenitally Corrected Transposition of Great Arteries.
Sudden Cardiac Death and Myocardial Fibrosis, Determined by Autopsy, in Persons with HIV.
Predictors of long-term success after catheter ablation of premature ventricular complexes.
Cardiac arrhythmia spot light: Detection of ventricular fibrillation-Not all ICDs are created equal.
Factors Predisposing to Survival After Resuscitation for Sudden Cardiac Arrest.
Second-Degree Atrioventricular Block-Reply.
Sex and Racial Differences in Autopsy-Defined Causes of Presumed Sudden Cardiac Death.
Incident Strokes Among American Indian Individuals With Atrial Fibrillation.
Antemortem and Post-Mortem Characteristics of Lethal Mitral Valve Prolapse Among All Countywide Sudden Deaths.
Presumed Sudden Cardiac Deaths in the PARADIGM-HF Trial.
A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Alcohol to Assess Changes in Atrial Electrophysiology.
Electrophysiologic approach to diagnosis and ablation of patients with permanent junctional reciprocating tachycardia associated with complex anatomy and/or physiology.
The Weak LINQ-Continuous Rhythm Monitoring During Sudden Death.
Occult Overdose Masquerading as Sudden Cardiac Death: From the POstmortem Systematic InvesTigation of Sudden Cardiac Death Study.
Preserving Access to the Invaluable Clinical Autopsy.
Placental Abruption as a Risk Factor for Heart Failure.
Long-term outcomes of ablation for ventricular arrhythmias in mitral valve prolapse.
Association of QT-Prolonging Medications With Risk of Autopsy-Defined Causes of Sudden Death.
Predictors of adverse outcome in patients with frequent premature ventricular complexes: The ABC-VT risk score.
Human Immunodeficiency Virus Infection and Incident Atrial Fibrillation.
Clinical Outcomes During Admissions for Heart Failure Among Adults With Congenital Heart Disease.
Presumed Sudden Cardiac Deaths Among Persons With HIV and Heart Failure.
Refining the World Health Organization Definition: Predicting Autopsy-Defined Sudden Arrhythmic Deaths Among Presumed Sudden Cardiac Deaths in the POST SCD Study.
Surface ECG and intracardiac spectral measures predict atrial fibrillation recurrence after catheter ablation.
Irregular Narrow Complex Tachycardia in the Setting of Congenital Heart Disease.
Sudden Cardiac Deaths-WHO Says They Are Always Arrhythmic?
Prospective Countywide Surveillance and Autopsy Characterization of Sudden Cardiac Death: POST SCD Study.
Use of Programmed Ventricular Extrastimulus During Supraventricular Tachycardia to Differentiate Atrioventricular Nodal Re-Entrant Tachycardia From Atrioventricular Re-Entrant Tachycardia.
Author response: Underestimation of sudden deaths among patients with seizures and epilepsy.
National Association of Medical Examiners Position Paper: Recommendations for the Investigation and Certification of Deaths in People with Epilepsy.
Atrial fibrillation patients with isolated pulmonary veins: Is sinus rhythm achievable?
Pulmonary and cardiac pathology in sudden unexpected death in epilepsy (SUDEP).
Maternal and Fetal Outcomes of Admission for Delivery in Women With Congenital Heart Disease.
Commentary on: Mauf S, Jentzsch T, Laberke PJ, Thali MJ, Bartsch C. Why we need postmortem analysis of cardiac implantable electronic devices. J Forensic Sci 2016;61(4):988-92.
The QT Interval as a Noninvasive Marker of Atrial Refractoriness.
Comparison of remote magnetic navigation ablation and manual ablation of idiopathic ventricular arrhythmia after failed manual ablation.
Clinical and Electrophysiological Characteristics of Incessant Atrioventricular Nodal Re-Entrant Tachycardia.
Risk of Cardiovascular Implantable Electronic Device Malfunction With Radiation Therapy: Location, Dose, or Energy?
Sudden Death in Patients With Cardiac Implantable Electronic Devices.
The Effect of Direct Current Stimulation versus T-Wave Shock on Defibrillation Threshold Testing.
Congenital heart disease in the older adult: a scientific statement from the American Heart Association.
Arrhythmias in Complex Congenital Heart Disease.
Utility of the exercise electrocardiogram testing in sudden cardiac death risk stratification.
Safety of radiofrequency catheter ablation without coronary angiography in aortic cusp ventricular arrhythmias.
Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy.
Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation.
Effect of left ventricular dysfunction and viral load on risk of sudden cardiac death in patients with human immunodeficiency virus.
Sudden death due to nonarrhythmic cause in a patient with L-TGA.
Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study).
PR Interval and sudden cardiac death in patients with HIV infection.
Diagnosis and ablation of multiform fascicular tachycardia.
Sudden cardiac death in patients with human immunodeficiency virus infection.
Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation.
Predictors of fluoroscopy time and procedural failure during biventricular device implantation.
Characteristics of sudden arrhythmic death in a diverse, urban community.
Funding source and author affiliation in TASER research are strongly associated with a conclusion of device safety.
Predictors of axillary vein location for vascular access during pacemaker and defibrillator lead implantation.
Risk factor and prediction modeling for sudden cardiac death in women with coronary artery disease.
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
Predictors of unusual ECG characteristics in cavotricuspid isthmus-dependent atrial flutter ablation.
Prospective observations in the clinical and electrophysiological characteristics of intra-isthmus reentry.
Changing QRS Morphology in a Patient with Wolff-Parkinson-White Syndrome.
Persistent Long R-P Tachycardia.
Supraventricular Tachycardia After Atrial Fibrillation Ablation.
Ventricular Tachycardia After Implantable Cardioverter-Defibrillator Placement.
Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease.
Test characteristics of neck fullness and witnessed neck pulsations in the diagnosis of typical AV nodal reentrant tachycardia.
Relation of Taser (electrical stun gun) deployment to increase in in-custody sudden deaths.
Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure time.
Rates and severity of perforation from implantable cardioverter-defibrillator leads: a 4-year study.
Impact of advanced age on survival in patients with implantable cardioverter defibrillators.
Protracted CRP elevation after atrial fibrillation ablation.
Kidney dysfunction and sudden cardiac death among women with coronary heart disease.
Alcohol intake is significantly associated with atrial flutter in patients under 60 years of age and a shorter right atrial effective refractory period.
Sudden cardiac death: epidemiology, mechanisms, and therapy.
Impact of renal function on survival in patients with implantable cardioverter-defibrillators.
Repeat transseptal catheterization after ablation for atrial fibrillation.
Three leads via the coronary sinus.
Threentry: what is the mechanism?
A unique method by which to quantitate synchrony with equilibrium radionuclide angiography.
Effects of resynchronization therapy on cardiac function in pacemaker patients "upgraded" to biventricular devices.
Catecholamine dependent accessory pathway automaticity.
Famotidine and long QT syndrome.
A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.
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