Journal of the American Society of Nephrology

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Repurposing Calcium-Sensing Receptor Activator Cinacalcet for Autosomal Dominant Polycystic Kidney Disease Treatment.

Journal of the American Society of Nephrology

Pattareeya Yottasan, Qi Tifany Chu, Onur Cil

mTORC2 Is Essential for Sodium-Glucose Cotransporter 2.

Journal of the American Society of Nephrology

Waheed Shabbir, John E. Demko, Enzo Takagi, Bidisha Saha, Deise C. Leite-Dellova, Bharathi Sambandam, David Pearce

Structural Determinants of mTORC2 Substrate Specificity and SGK1 Phosphorylation Revealed by Cryogenic Electron Microscopy.

Journal of the American Society of Nephrology

Junliang Chen, Zanlin Yu, Feng Wang, Xi Liu, Enzo Takagi, Lydia-Marie Joubert, Mingliang Jin, Carlos Nowotny, David Agard, Yifan Cheng, David Pearce

Role of mTORC2/SGK1 Signaling in Rapid Response to Acute K Load to Maintain K+ Homeostasis.

Journal of the American Society of Nephrology

Bidisha Saha, Waheed Shabbir, Enzo Takagi, John E. Demko, Mads V. Sorensen, Deise C. Leite-Dellova, David Pearce

Role of WNK1 and WNK4 in Sensing Extracellular Potassium in Principal Cells to Modulate mTORC2-Dependent Activation of Epithelial Sodium Channel.

Journal of the American Society of Nephrology

Bidisha Saha, Waheed Shabbir, Enzo Takagi, Mads V. Sorensen, Deise C. Leite-Dellova, David Pearce

Hyperpolarized MRI Detection of Dapagliflozin Effect on Gluconeogenesis in Live Animals: Proof of Principle.

Journal of the American Society of Nephrology

Waheed Shabbir, Enzo Takagi, Michael Ohliger, David Pearce

Small Molecule Inhibitor of TMEM16A Chloride Channel Blocks Vascular Smooth Muscle Contraction and Lowers Blood Pressure in Spontaneously Hypertensive Rats.

Journal of the American Society of Nephrology

Onur Cil, Xiaolan Chen, Henry Askew Page, Maria C. Jordan, Pyone Myat Thwe, Samuel N. Baldwin, Marc O. Anderson, Iain A. Greenwood, Kenneth P. Roos, Alan S. Verkman

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