Submitted by kanopi on Feb 28, 2018
Kv7 channels are central to the control of excitation in the heart and brain, and harbor disease mutations associated with arrhythmias, epilepsy, and deafness. The calcium sensor protein calmodulin controls the action of Kv7 channels and provides a key link between channel activity and cellular signaling pathways. In this video, members from the Minor Lab describe their recent studies published in Neuron that uncover a universal mechanism by which calmodulin controls Kv7 channels through an Apo/CaM clamp and a C-lobe-driven switch mechanism.
