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Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.

Nature

Wilson CW, Nguyen CT, Chen MH, Yang JH, Gacayan R, Huang J, Chen JN, Chuang PT

The unfolded protein response signals through high-order assembly of Ire1.

Nature

Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

Nature

Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM

The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency.

Nature

Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim WA

SMAD proteins control DROSHA-mediated microRNA maturation.

Nature

Davis BN, Hilyard AC, Lagna G, Hata A

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

Nature

King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, Zuzow R, Dirks W, Good M, Goodstein D, Lemons D, Li W, Lyons JB, Morris A, Nichols S, Richter DJ, Salamov A, Sequencing JG, Bork P, Lim WA, Manning G, Miller WT, McGinnis W, Shapiro H, Tjian R, Grigoriev IV, Rokhsar D

Structural basis for the function and inhibition of an influenza virus proton channel.

Nature

Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Nature

Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J

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