Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies
December 08, 2020
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the SARS-CoV-2 spike protein is an envelope glycoprotein that binds angiotensin converting enzyme 2 as an entry receptor. Pulmonary Division, Department of Medicine, Lung Biology Center, and Cardiovascular Research Institute Faculty Search
October 28, 2020
UCSF School of Medicine and Zuckerberg San Francisco General Hospital
Pulmonary Division, Department of Medicine, Lung Biology Center, and Cardiovascular Research Institute Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cell
October 14, 2020
In major cardiovascular diseases, including stroke and heart attack, loss of blood flow causes loss of oxygen (ischemia), leading to tissue damage and cell deaths. A species of ground squirrels from the Arctic can tolerate such ischemic attack, but the underlying biological basis has been unknown. The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia
October 12, 2020
In a clinical collaboration with Melvin Scheinman from the UCSF Comprehensive Genetic Arrythmia Program, CVRI investigators Rahul Deo and Natalia Jura, along with MD/PhD trainee Erron Titus, set out to explain how mutations in the calcium-storage protein, calsequestrin, cause lethal arrhthymias.... A digital biomarker of diabetes from smartphone-based vascular signals
August 17, 2020
The global burden of diabetes is rapidly increasing, from 451 million people in 2019 to 693 million by 2045 These San Francisco doctors flew to New York to fight the coronavirus — and they have a warning for us
July 07, 2020
When Dr. Ethan Weiss arrived in New York in late April, he started his first shift almost immediately. UCSF studying stem cells as possible coronavirus treatment
June 11, 2020
UCSF’s Dr. Michael Matthay wasn’t thinking about a pandemic in January when he launched a clinical trial to investigate whether certain stem cells could effectively treat a serious form of respiratory failure. 2020 Chen Award for Distinguished Academic Achievement in Human Genetic and Genomic Research
April 05, 2020
Pui-Yan Kwok, MD, PhD This award is to celebrate the achievement of a biomedical scientist: Remembering John F. Murray, MD
April 02, 2020
It is with great sadness that we share the news that John F. Murray, Professor of Medicine emeritus, has passed away.