Professor
Medicine
Research Interests
Integrative Biology of Heart Rhythm: Development, Physiology, Genetics, and Disease
Email
Websites
Faculty Type
Core CVRI Faculty
Research Summary:
The goals of our research program are to understand the molecular, cellular, and developmental basis for the initiation and propagation of the heartbeat; to understand the pathophysiology of common and rare arrhythmia syndromes using human genetics, animal models, and human iPSC-derived heart cells and tissues; and to leverage our scientific discoveries to restore normal heart rhythm to patients suffering from slow heartbeat, irregular heartbeat (atrial fibrillation), and cardiac arrest.
Publications
ALPK3 Heterozygous Truncating Variants Cause Late-Onset Hypertrophic Cardiomyopathy With Frequent Apical Involvement and Apical Aneurysm.
Circulation. Genomic and precision medicine
Flecainide for the Treatment of Andersen-Tawil Syndrome.
JACC. Clinical electrophysiology
RACE COMPARISONS FROM THE CARDIAC SARCOIDOSIS CONSORTIUM: BLACK CARDIAC SARCOIDOSIS PATIENTS HAVE HIGHER RATES OF COMORBIDITIES.
Journal of the American College of Cardiology
RISK OF ADVERSE OUTCOMES ASSOCIATED WITH INITIAL CLINICAL PRESENTATION OF CARDIAC SARCOIDOSIS.
Journal of the American College of Cardiology
ALPK3 heterozygous truncating variants cause late-onset hypertrophic cardiomyopathy with frequent apical involvement and apical aneurysm.
medRxiv : the preprint server for health sciences
MP-470554-001 THE VALUE OF FUNCTIONAL FACSICULAR BLOCK IN PATIENTS WITH ATRIOVENTRICULAR REENTRANT TACHYCARDIA.
Heart rhythm
SEX DIFFERENCES IN CARDIAC SARCOIDOSIS TREATMENT AND OUTCOMES: FINDINGS FROM THE CARDIAC SARCOIDOSIS CONSORTIUM.
Journal of the American College of Cardiology
Acute alcohol exposure and electrocardiographic changes: Finding from the HOLIDAY trial.
Journal of electrocardiology
Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes.
Frontiers in physiology
Reply: Association of Adverse Events With the Different Diagnostic Schemes of Cardiac Sarcoidosis.
JACC. Clinical electrophysiology
Single Cell Multi-Omics of an iPSC Model of Human Sinoatrial Node Development Reveals Genetic Determinants of Heart Rate and Arrhythmia Susceptibility.
bioRxiv : the preprint server for biology
Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes.
bioRxiv : the preprint server for biology
A very wide complex tachycardia.
Heart rhythm
Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes.
JACC. Clinical electrophysiology
ACUTE ALCOHOL EXPOSURE AND ELECTROCARDIOGRAPHIC CHANGES: FINDING FROM THE HOLIDAY (HOW ALCOHOL INDUCES ATRIAL TACHYARRHYTHMIAS) TRIAL.
Journal of the American College of Cardiology
A Randomized Trial of High vs Standard Power Radiofrequency Ablation for Pulmonary Vein Isolation: SHORT-AF.
JACC. Clinical electrophysiology
Premature Atrial Contraction Location and Atrial Fibrillation Inducibility.
Circulation. Arrhythmia and electrophysiology
Randomized Comparison of a Radiofrequency Wire Versus a Radiofrequency Needle System for Transseptal Puncture.
JACC. Clinical electrophysiology
The Value of Programmed Ventricular Extrastimuli From the Right Ventricular Basal Septum During Supraventricular Tachycardia.
JACC. Clinical electrophysiology
Arrhythmia Monitoring and Outcomes in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.
Journal of the American Heart Association
CARDIAC SARCOIDOSIS PATIENTS WHO MEET THE 1993 AND 2006 JAPANESE DIAGNOSTIC CRITERIA ARE MORE LIKELY TO HAVE ADVERSE OUTCOMES.
Journal of the American College of Cardiology
TRADITIONAL RISK FACTORS INCREASE THE RISK OF POOR OUTCOMES IN PATIENTS WITH CARDIAC SARCOIDOSIS.
Journal of the American College of Cardiology
Outcomes Associated With Catheter Ablation of Ventricular Tachycardia in Patients With Cardiac Sarcoidosis.
JAMA cardiology
Acute Consumption of Alcohol and Discrete Atrial Fibrillation Events.
Annals of internal medicine
Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node.
Frontiers in physiology
Predictors of long-term success after catheter ablation of premature ventricular complexes.
Journal of cardiovascular electrophysiology
The Role of the Left Septal Fascicle in Fascicular Arrhythmias: Clinical Presentation and Laboratory Evaluation.
JACC. Clinical electrophysiology
Heart Failure, Atrioventricular Block, and Ventricular Tachycardia in Sarcoidosis.
Journal of the American Heart Association
A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Alcohol to Assess Changes in Atrial Electrophysiology.
JACC. Clinical electrophysiology
Abstract 12935: Predictors of Long-term Success After Catheter Ablation of Premature Ventricular Complexes.
Circulation
Electrophysiologic approach to diagnosis and ablation of patients with permanent junctional reciprocating tachycardia associated with complex anatomy and/or physiology.
Journal of cardiovascular electrophysiology
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.
Circulation research
Predictors of adverse outcome in patients with frequent premature ventricular complexes: The ABC-VT risk score.
Heart rhythm
Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.
Journal of the American Heart Association
Ischemia with marked ST elevation or J-wave syndrome?
Journal of electrocardiology
Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System.
Frontiers in physiology
Surface ECG and intracardiac spectral measures predict atrial fibrillation recurrence after catheter ablation.
Journal of cardiovascular electrophysiology
Use of Programmed Ventricular Extrastimulus During Supraventricular Tachycardia to Differentiate Atrioventricular Nodal Re-Entrant Tachycardia From Atrioventricular Re-Entrant Tachycardia.
JACC. Clinical electrophysiology
Trends in Hospitalizations for Cardiac Sarcoidosis in the United States, 2005-2011.
Circulation journal : official journal of the Japanese Circulation Society
Cover Image, Volume 28, Issue 7.
Journal of cardiovascular electrophysiology
Atrial fibrillation patients with isolated pulmonary veins: Is sinus rhythm achievable?
Journal of cardiovascular electrophysiology
Familial inappropriate sinus tachycardia: a new chapter in the story of HCN4 channelopathies.
European heart journal
Bundle Branch Re-Entrant Ventricular Tachycardia: Novel Genetic Mechanisms in a Life-Threatening Arrhythmia.
JACC. Clinical electrophysiology
The QT Interval as a Noninvasive Marker of Atrial Refractoriness.
Pacing and clinical electrophysiology : PACE
Clinical and Electrophysiological Characteristics of Incessant Atrioventricular Nodal Re-Entrant Tachycardia.
JACC. Clinical electrophysiology
POST-SHOCK ELECTROMECHANICAL DISSOCIATION DURING DEFIBRILLATION THRESHOLD TESTING.
Journal of the American College of Cardiology
New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development.
Trends in molecular medicine
Response to letter regarding article, "variable clinical features and ablation of manifest nodofascicular/ventricular pathways".
Circulation. Arrhythmia and electrophysiology
The Effect of Direct Current Stimulation versus T-Wave Shock on Defibrillation Threshold Testing.
Pacing and clinical electrophysiology : PACE
RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.
Circulation research
Atrial Fibrillation.
Manual of Electrophysiology
Variable clinical features and ablation of manifest nodofascicular/ventricular pathways.
Circulation. Arrhythmia and electrophysiology
Idiopathic ventricular arrhythmia originating from the cardiac crux or inferior septum: epicardial idiopathic ventricular arrhythmia.
Circulation. Arrhythmia and electrophysiology
Specification of the mouse cardiac conduction system in the absence of Endothelin signaling.
Developmental biology
Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy.
Journal of cardiovascular electrophysiology
Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study).
Journal of the American Heart Association
Unexpected potential following ablation of a right atriofascicular accessory pathway.
Journal of cardiovascular electrophysiology
Narrow QRS Tachycardia with Ventriculoatrial Block.
Cardiac electrophysiology clinics
Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning.
Developmental biology
Ivabradine: a ray of hope for inappropriate sinus tachycardia.
Journal of the American College of Cardiology
Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation.
The American journal of cardiology
Predictors of fluoroscopy time and procedural failure during biventricular device implantation.
The American journal of cardiology
PREDICTORS OF PROCEDURAL DIFFICULTY DURING BIVENTRICULAR DEVICE IMPLANTATION: A UNIVERSITY HOSPITAL EXPERIENCE.
Journal of the American College of Cardiology
Chapter 33 Current Indications for Temporary and Permanent Cardiac Pacing.
Electrophysiological Disorders of the Heart
Abstract 10466: In Vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes.
Circulation
Changing QRS Morphology in a Patient with Wolff-Parkinson-White Syndrome.
Cardiac electrophysiology clinics
Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels.
Biophysical Journal
The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels.
The Journal of general physiology
Slow inactivation does not affect movement of the fast inactivation gate in voltage-gated Na+ channels.
The Journal of general physiology
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