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A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

Cell

Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.

Cell

Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.

Cell

Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.

Cell

Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A

The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells.

Cell

Zhang JR, Mostov KE, Lamm ME, Nanno M, Shimida S, Ohwaki M, Tuomanen E

The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.

Cell

Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM

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