Vasanth Vedantham, MD, PhD

Vedantham
Associate Professor
Medicine
Research Interests
Integrative Biology of Heart Rhythm: Development, Physiology, Genetics, and Disease
Faculty Type
Core CVRI Faculty

Research Summary:
Development and function of the cardiac conduction system; molecular regulation of cardiac pacemaker cells; mechanisms of cardiac arrhythmias   Our lab is focused on cardiac pacemaker cells, specialized cardiomyocytes whose autonomous electrical activity allows the sinoatrial node to serve as the heart’s natural pacemaker. Specific questions include: How are pacemaker cells different from regular heart cells at the level of gene expression and regulation? How does their unique gene expression signature confer their distinctive electrophysiological properties? How have selection pressures generated functional differences in pacemaker cells among different vertebrate species? What are the molecular mechanisms that guide pacemaker cells to integrate electrically with the rest of the heart to form a node? How do pacemaker cell biology and function change in response to physiological and pathological stress? What is the mechanistic link between sinus node dysfunction and atrial fibrillation? Our approaches include mouse genetics, whole-animal and ex-vivo electrophysiology, cellular and molecular electrophysiology, gene expression analysis, and bioinformatics. Ultimately, we hope to design novel treatments for patients suffering from heart rhythm disorders, including sinus node dysfunction and atrial fibrillation.

Publications

Flecainide for the Treatment of Andersen-Tawil Syndrome.

JACC. Clinical electrophysiology

Mann TD, Yoruk A, Neves RA, Bergman AT, Bos MJ, van der Werf C, Gollob MH, Roberts JD, Khan H, Sanatani S, Vedantham V, Lee BK, Yesaulov A, Krahn AD, Tadros R, Wilde AA, Ackerman MJ, Scheinman MM

RACE COMPARISONS FROM THE CARDIAC SARCOIDOSIS CONSORTIUM: BLACK CARDIAC SARCOIDOSIS PATIENTS HAVE HIGHER RATES OF COMORBIDITIES.

Journal of the American College of Cardiology

Esteban De La Rosa Martinez, Angkawipa Trongtorsak, Thomas C. Crawford, Frank M. Bogun, Xiaokui Gu, Kenneth A. Ellenbogen, Alexandru B. Chicos, Henri Roukoz, Peter J. Zimetbaum, Steven Jack Kalbfleisch, Francis D. Murgatroyd, David Steckman, Lynda E. Rosenfeld, Kyoko Soejima, Adarsh K. Bhan, Vasanth Vedantham, Timm-Michael L. Dickfeld, David B. De Lurgio, Pyotr G. Platonov, Matthew Michael Zipse, Matthew L. Ortman, Calambur Narasimhan, Kristen K. Patton, David Rosenthal, Jordana Kron

RISK OF ADVERSE OUTCOMES ASSOCIATED WITH INITIAL CLINICAL PRESENTATION OF CARDIAC SARCOIDOSIS.

Journal of the American College of Cardiology

Kevin J. Wunderly, Xiaokui Gu, Eric Puroll, Jordana Kron, Muhammad Rizwan Afzal, Alexandru B. Chicos, Henri Roukoz, Peter J. Zimetbaum, Francis D. Murgatroyd, Mikhail Torosoff, Pyotr G. Platonov, Adarsh K. Bhan, Kyoko Soejima, Kristen K. Patton, Matthew Michael Zipse, William H. Sauer, Eva M. Kline-Rogers, Matthew L. Ortman, Vasanth Vedantham, Ann C. Garlitski, Katja Zeppenfeld, Frank M. Bogun, James B. Froehlich, Kim A. Eagle, Thomas C. Crawford

SEX DIFFERENCES IN CARDIAC SARCOIDOSIS TREATMENT AND OUTCOMES: FINDINGS FROM THE CARDIAC SARCOIDOSIS CONSORTIUM.

Journal of the American College of Cardiology

Dhuha Manhil, Thomas C. Crawford, Frank M. Bogun, Xiaokui Gu, Alexandru B. Chicos, Henri Roukoz, Peter J. Zimetbaum, Francis D. Murgatroyd, Lynda E. Rosenfeld, Kyoko Soejima, Adarsh K. Bhan, Vasanth Vedantham, Timm-Michael L. Dickfeld, David B. De Lurgio, Pyotr G. Platonov, Calambur Narasimhan, Kristen K. Patton, David Rosenthal, SIDDHARTH S. MUKERJI, Christopher Madias, Steven Jack Kalbfl eisch, Mikhail Torosoff, Kenneth A. Ellenbogen, Jordana Kron

Reply: Association of Adverse Events With the Different Diagnostic Schemes of Cardiac Sarcoidosis.

JACC. Clinical electrophysiology

Myadam R, Crawford TC, Bogun FM, Gu X, Ellenbogen KA, Jasti S, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Garlitski AC, Soejima K, Bhan AK, Vedantham V, Dickfeld TL, De Lurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium

Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes.

JACC. Clinical electrophysiology

Myadam R, Crawford TC, Bogun FM, Gu X, Ellenbogen KA, Jasti S, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Garlitski AC, Soejima K, Bhan AK, Vedantham V, Dickfeld TL, De Lurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium

Arrhythmia Monitoring and Outcomes in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium.

Journal of the American Heart Association

Bressi E, Crawford TC, Bogun FM, Gu X, Ellenbogen KA, Chicos AB, Roukoz H, Zimetbaum PJ, Kalbfleisch SJ, Murgatroyd FD, Steckman DA, Rosenfeld LE, Garlitski AC, Soejima K, Bhan AK, Vedantham V, Dickfeld TM, De Lurgio DB, Platonov PG, Zipse MM, Nishiuchi S, Ortman ML, Narasimhan C, Patton KK, Rosenthal DG, Mukerji SS, Hoogendoorn JC, Zeppenfeld K, Sauer WH, Kron J, Cardiac Sarcoidosis Consortium *

CE-522-04 MORTALITY AND MORBIDITY OF CARDIAC SARCOIDOSIS: AN INTERNATIONAL REGISTRY.

Heart rhythm

Thomas C. Crawford, Jordana Kron, Xiaokui Gu, M. Rizwan Afzal, Alexandru B. Chicos, Henri Roukoz, Peter J. Zimetbaum, Francis D. Murgatroyd, Kathryn Martin, Mikhail Torosoff, David A. Steckman, Pyotr G. Platonov, Adarsh K. Bhan, Lynda E. Rosenfeld, David B. De Lurgio, Ann C. Garlitski, Vasanth Vedantham, Kyoko Soejima, Jason Appelbaum, Timm-Michael Dickfeld, Matthew L. Ortman, Kazuaki Kaitani, Suguru Nishiuchi, Calambur Narasimhan, Kristen K. Patton, David Rosenthal, Khaled Nour, Siddharth S. Mukerji, Katja Zeppenfeld, Matthew M. Zipse, Marc Judson, Marc Judson, William H. Sauer, Kenneth A. Ellenbogen, James Froehlich, Kim A. Eagle, Frank M. Bogun

CARDIAC SARCOIDOSIS PATIENTS WHO MEET THE 1993 AND 2006 JAPANESE DIAGNOSTIC CRITERIA ARE MORE LIKELY TO HAVE ADVERSE OUTCOMES.

Journal of the American College of Cardiology

Shilpa Jasti, Muhammad Afzal, Steven Jack Kalbfleisch, Kenneth A. Ellenbogen, Frank M. Bogun, Alexandru B. Chicos, Henri Roukoz, Peter J. Zimetbaum, Francis Murgatroyd, Mikhail Torosoff, Marc Judson, Pyotr G. Platonov, Adarsh K. Bhan, Lynda E. Rosenfeld, David B. De Lurgio, Ann C. Garlitski, Melody H. Hermel, Vasanth Vedantham, Kyoko Soejima, Timm-Michael L. Dickfeld, Xiaokui Gu, Eric Puroll, Thomas C. Crawford, Jordana Kron

TRADITIONAL RISK FACTORS INCREASE THE RISK OF POOR OUTCOMES IN PATIENTS WITH CARDIAC SARCOIDOSIS.

Journal of the American College of Cardiology

Shilpa Jasti, Muhammad Afzal, Steven Jack Kalbfleisch, Kenneth A. Ellenbogen, Frank M. Bogun, Alexandru B. Chicos, Henri Roukoz, Peter J. Zimetbaum, Francis Murgatroyd, Mikhail Torosoff, Marc Judson, Pyotr G. Platonov, Adarsh K. Bhan, Lynda E. Rosenfeld, David B. De Lurgio, Ann C. Garlitski, Melody H. Hermel, Vasanth Vedantham, Kyoko Soejima, Timm-Michael L. Dickfeld, Xiaokui Gu, Eric Puroll, Thomas C. Crawford, Jordana Kron

B-PO02-152 ELECTROCARDIOGRAPHIC CHANGES IN A DOUBLE-BLIND, PLACEBO-CONTROLLED RANDOMIZED TRIAL OF ETHANOL VERSUS PLACEBO.

Heart rhythm

Monica Tung, Eric Vittinghoff, Gregory Nah, David G. Rosenthal, Nitish Badhwar, Jonathan W. Dukes, Joshua D. Moss, Randall J. Lee, Byron Lee, Zian H. Tseng, Tomos E. Walters, Vasanth Vedantham, Rachel A. Gladstone, Shannon Mei-ling Fan, Christina D. Fang, Kelsey Ogomori, Emily Lee, Trisha F. Hue, Jeffrey E. Olgin, Melvin M. Scheinman, Vijay Ramchandani, Henry H. Hsia, Edward P. Gerstenfeld, Gregory M. Marcus

Cover Image, Volume 28, Issue 7.

Journal of cardiovascular electrophysiology

Judit Szilágyi, Gregory M. Marcus, Nitish Badhwar, Byron K. Lee, Randall J. Lee, Vasanth Vedantham, Zian H. Tseng, Tomos Walters, Melvin Scheinman, Jeffrey Olgin, Edward P. Gerstenfeld

Address

555 & 535 Mission Bay Blvd Sou, Rm 352M
UCSF Box 3120
San Francisco, CA 94158
United States